Epstein-barr virus negative clonal plasma cell proliferations and lymphomas in peripheral T-cell lymphomas: A phenomenon with distinctive clinicopathologic features

Olga Balagué, Antonio Martínez, Luís Colomo, Ester Roselló, Adriana Garcia, Mónica Martínez-Bernal, Antonio Palacín, Kai Fu, Dennis Weisenburger, Dolors Colomer, Jerome S. Burke, Roger A. Warnke, Elías Campo

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Abstract

Clonal B-cell populations have been described in peripheral T-cell lymphomas (PTCL) as secondary Epstein-Barr virus (EBV) driven B-cell expansions that may evolve to an overt B-cell lymphoma. EBV-negative B-cell proliferations associated with T-cell lymphomas are uncommon and not well characterized. We studied 15 patients who developed an EBV-negative B-cell proliferation or malignant lymphoma associated with PTCL. The T-cell tumors were 8 PTCL, not otherwise specified, 4 angioimmunoblastic T-cell lymphomas, and 3 cutaneous PTCL. The B-cell component was intermingled with the PTCL in all patients and it was classified as clonal/monotypic plasma cell proliferation in 8 lesions, clonal/monotypic large B-cell proliferation in 4 patients, and B-cell lymphoma with plasmacytic/plasmablastic differentiation in 3 patients. Two patients had 2 clonally unrelated plasma cell proliferations associated with the same PTCL. All cases showed cytoplasmic Ig light chain restriction. Clonal IgH and T-cell receptor rearrangements were detected in 11/12 and 11/13 cases examined, respectively. EBV, cytomegalovirus, and HHV-8 were not observed in any of the examined cases. Sequential samples in 7 patients showed persistence of the PTCL and the B-cell component in 4, the PTCL without the B-cell lymphoma in 2, and progression of the B-cell neoplasm in 1. Patients followed an aggressive clinical course similar to conventional PTCL. In conclusion, EBV-negative clonal or mononotypic B-cell proliferations in patients with PTCL present with a spectrum of lesions ranging from plasma cell proliferations to overt lymphomas with plasmacytic/plasmablastic features. The distinctive features of these patients suggest that these lesions represent a specific phenomenon in PTCL.

Original languageEnglish (US)
Pages (from-to)1310-1322
Number of pages13
JournalAmerican Journal of Surgical Pathology
Volume31
Issue number9
DOIs
StatePublished - Sep 1 2007

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Keywords

  • Angioimmunoblastic T-cell lymphoma
  • B-cell clones
  • Epstein-Barr virus
  • Peripheral T-cell lymphoma
  • Plasmablastic lymphoma
  • Plasmacytoma

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

Cite this

Balagué, O., Martínez, A., Colomo, L., Roselló, E., Garcia, A., Martínez-Bernal, M., Palacín, A., Fu, K., Weisenburger, D., Colomer, D., Burke, J. S., Warnke, R. A., & Campo, E. (2007). Epstein-barr virus negative clonal plasma cell proliferations and lymphomas in peripheral T-cell lymphomas: A phenomenon with distinctive clinicopathologic features. American Journal of Surgical Pathology, 31(9), 1310-1322. https://doi.org/10.1097/PAS.0b013e3180339f18