Equivalence and noninferiority trials are becoming more common in the medical literature. Because many disease processes have well-established therapeutic regimens, equivalence and noninferiority trials are helpful tools to evaluate novel therapeutics. This allows the researcher to compare to the standard of care rather than placebo, which in many instances would be undesirable or even unethical. Understanding and implementing proper study design, as well as avoiding potential pitfalls, are important to obtain results with clinical relevance and credibility.
|Original language||English (US)|
|Title of host publication||Handbook for Designing and Conducting Clinical and Translational Surgery|
|Number of pages||7|
|State||Published - Jan 1 2023|
- Equivalence margin
- Two one-sided test
ASJC Scopus subject areas