Equivalence and noninferiority

Philip McCarthy, Benjamin Acton, Jessica Maxwell

Research output: Chapter in Book/Report/Conference proceedingChapter


Equivalence and noninferiority trials are becoming more common in the medical literature. Because many disease processes have well-established therapeutic regimens, equivalence and noninferiority trials are helpful tools to evaluate novel therapeutics. This allows the researcher to compare to the standard of care rather than placebo, which in many instances would be undesirable or even unethical. Understanding and implementing proper study design, as well as avoiding potential pitfalls, are important to obtain results with clinical relevance and credibility.

Original languageEnglish (US)
Title of host publicationHandbook for Designing and Conducting Clinical and Translational Surgery
Number of pages7
ISBN (Electronic)9780323903004
StatePublished - Jan 1 2023


  • Equivalence
  • Equivalence margin
  • Noninferiority
  • TOST
  • Two one-sided test

ASJC Scopus subject areas

  • General Medicine


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