Mishra PK, Adameova A, Hill JA, Baines CP, Kang PM, Downey JM, Narula J, Takahashi M, Abbate A, Piristine HC, Kar S, Su S, Higa JK, Kawasaki NK, Matsui T. Guidelines for evaluating myocardial cell death. Am J Physiol Heart Circ Physiol 317: H891-H922, 2019. First published August 16, 2019; doi:10.1152/ajpheart.00259.2019."In this article, the abbreviation MPT for mitochondrial permeability transition was incorrectly represented as MTP in three places: second to last paragraph of OVERALL DISCUSSION AND CONCLUSIONS and Fig. 8 artwork and legend, as now corrected below. OVERALL DISCUSSION AND CONCLUSIONS To evaluate cell death, it is important to first assess whether the cells are dying by using a viability assay such as ATP/ADP ratio. Depending on cell membrane integrity, cell death mechanisms can be broadly categorized into two groups: 1) with intact cell membranes such as apoptosis, ferroptosis and autophagic cell death; and 2) necroptosis, mitochondrial permeability transition (MPT)-mediated necrosis, necroptosis, pyroptosis, and autosis with ruptured cell membranes. Thus, determining the cell membrane integrity could help only as an initial screen for cell death mechanisms. In each category, further assessment of the characteristic features will delineate the specific form of cell death (Fig. 8). (Figure Presented).
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Physiology (medical)