A 76-year-old woman had recurrent urosepsis due to extended-spectrum beta -lactamase-positive Escherichia coli. Imipenem resistance was detected after long-term imipenem-meropenem therapy. The carbapenem-hydrolyzing enzyme gene was identified as blaKPC-3. To our knowledge, this is the first documented case in which carbapenem-resistant E. coli emerged during therapy with imipenem and meropenem, and the first identification of the carbapenem-hydrolyzing enzyme in E. coli isolates.
|Original language||English (US)|
|Journal||Clinical infectious diseases : an official publication of the Infectious Diseases Society of America|
|State||Published - May 15 2005|
ASJC Scopus subject areas
- Microbiology (medical)
- Infectious Diseases