Escherichia coli O157:H7 induces attaching-effacing lesions in large intestinal mucosal explants from adult cattle

Angela A. Baehler, Rodney A. Moxley

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Attaching-effacing (A/E) lesions following natural and experimental infection with Escherichia coli O157:H7 have been seen in neonatal and 3-4-month-old weanling but not older cattle. To test the hypothesis that the adult bovine large intestinal epithelium is resistant to the development of A/E lesions, colonic and rectal mucosal tissue explants from 18-month-old steers were inoculated with E. coli O157:H7 and examined. Epithelial cells of inoculated explants developed A/E lesions at the bacterial attachment sites, providing evidence that the large intestinal mucosal epithelium may be a site of infection that contributes to carriage of E. coli O157:H7 in adult cattle. Copyright (C) 2000.

Original languageEnglish (US)
Pages (from-to)239-242
Number of pages4
JournalFEMS Microbiology Letters
Volume185
Issue number2
DOIs
StatePublished - Apr 15 2000

Keywords

  • Attaching-effacing
  • Cattle
  • Escherichia coli O157:H7
  • Explant
  • Large intestine

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology
  • Genetics

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