Esophageal cancer: Clinical Practice Guidelines in oncology™

Jaffer Ajani, Tanios Bekaii-Saab, Thomas A. D'Amico, Charles Fuchs, Michael K. Gibson, Melvyn Goldberg, James A. Hayman, David H. Ilson, Milind Javle, Scott Kelley, Robert C. Kurtz, Gershon Yehuda Locker, Neal J. Meropol, Bruce D. Minsky, Mark B. Orringer, Raymond U. Osarogiagbon, James A. Posey, Jack Roth, Aaron R. Sasson, Stephen G. SwisherDouglas E. Wood, Yun Yen

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations


Esophageal cancer is a major health hazard in many parts of the world. The incidence of adenocarcinoma is increasing in white men, particularly in the nonendemic areas such as North America and many Western European countries. Barrett's metaplasia, gastroesophageal reflux, hiatal hernia, and obesity are believed to be contributing factors. In addition, the most common location of esophageal carcinoma has shifted to the lower third of the esophagus. Unfortunately, esophageal carcinoma is often diagnosed late and, therefore, most therapeutic approaches are palliative. Advances have been made in staging procedures and therapeutic approaches. The guidelines emphasize that palpable advances have been made in the treatment of locoregional esophageal carcinoma. Similarly, endoscopic palliation of esophageal carcinoma has improved substantially because of improving technology. New chemotherapeutic agents are on the horizon, including antireceptor agents, vaccines, gene therapy, and anti-angiogenic agents. The panel expects numerous future advances in the treatment of esophageal carcinoma.

Original languageEnglish (US)
Pages (from-to)328-347
Number of pages20
JournalJNCCN Journal of the National Comprehensive Cancer Network
Issue number4
StatePublished - Apr 2006


  • Chemoradiation
  • Chemotherapy
  • Combined modality therapy
  • Esophageal carcinoma
  • NCCN Clinical Practice Guidelines
  • Resection
  • Surgery

ASJC Scopus subject areas

  • Oncology


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