Establishment of a long‐term adenocarcinoma of the prostate cell line in the nude mouse

S. D. Graham, S. H. Poulton, B. H. Woodard, K. W. Lyles, D. F. Paulson, J. Linder

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

There are few established human prostatic adenocarcinoma cell lines in existence. Most established lines are nonfunctional and hormonally insensitive. A human prostate adenocarcinoma (9479) has been serially transplanted for more than 4 years in athymic nude mice. The tumor is estrogen and androgen insensitive, is transplantable between mice with a high rate of success. The tumor does not produce enzymatically measurable acid phosphatase, but does produce immunologically identifiable acid phosphatase. Not only has the tumor retained its original morphology, it also appears to produce a factor producing hypophosphatemia. Current studies in regards to the endocrinological aspects of this tumor are in progress. We propose that acid phosphatase is produced, but in an altered form.

Original languageEnglish (US)
Pages (from-to)369-376
Number of pages8
JournalThe Prostate
Volume7
Issue number4
DOIs
StatePublished - 1985

Keywords

  • acid phosphatase
  • nude mice
  • prostatic adenocarcinoma

ASJC Scopus subject areas

  • Oncology
  • Urology

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    Graham, S. D., Poulton, S. H., Woodard, B. H., Lyles, K. W., Paulson, D. F., & Linder, J. (1985). Establishment of a long‐term adenocarcinoma of the prostate cell line in the nude mouse. The Prostate, 7(4), 369-376. https://doi.org/10.1002/pros.2990070405