Establishment of Reference Doses for residues of allergenic foods: Report of the VITAL Expert Panel

Steve L. Taylor, Joseph L. Baumert, Astrid G. Kruizinga, Benjamin C. Remington, Rene W.R. Crevel, Simon Brooke-Taylor, Katrina J. Allen, Geert Houben

Research output: Contribution to journalArticle

170 Scopus citations

Abstract

In 2011, an expert panel was assembled to establish appropriate Reference Doses for allergenic food residues as a part of the VITAL (Voluntary Incidental Trace Allergen Labeling) program of The Allergen Bureau of Australia & New Zealand (ABA). These Reference Doses would guide advisory labeling decisions for use on food labels. Individual NOAELs and LOAELs were obtained from clinical challenges of food-allergic subjects. Statistical dose-distribution models (log-normal, log-logistic, Weibull) were applied to the individual NOAELs and LOAELs for each allergenic food. The Reference Doses, in terms of mg of total protein from the allergenic food, were based upon either the ED01 (for peanut, cow's milk), the 95% lower confidence interval of the ED05 (for wheat, soybean, cashew, shrimp, sesame seed, mustard, and lupine), or both (egg, hazelnut) using all appropriate statistical dose-distribution models. Reference Doses were established for 11 allergenic foods ranging from 0.03mg for egg protein to 10mg for shrimp protein. Reference Doses were not established for fish or celery due to poor model fits with existing data. Reference Doses were not established for other tree nuts beyond hazelnut and cashew because of the absence of data on NOAELs and LOAELs from individual subjects.

Original languageEnglish (US)
Pages (from-to)9-17
Number of pages9
JournalFood and Chemical Toxicology
Volume63
DOIs
StatePublished - Jan 2014

Keywords

  • Allergy
  • Food
  • Labeling
  • Risk assessment
  • Threshold

ASJC Scopus subject areas

  • Food Science
  • Toxicology

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