Esterase-activated release of naproxen from supramolecular nanofibres

Martin Conda-Sheridan; Sungsoo S. Lee; Adam T. Preslar; Samuel I. Stupp

doi:10.1039/c4cc06340f

Esterase-activated release of naproxen from supramolecular nanofibres

Martin Conda-Sheridan, Sungsoo S. Lee, Adam T. Preslar, Samuel I. Stupp

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

Nanofibre forming peptide amphiphiles were conjugated to naproxen through an esterase-sensitive linker. The amount of naproxen released, in the presence of enzymes, was influenced by the linker conjugating the drug to the supramolecular assembly. In vitro studies showed the anti-inflammatory activity of the released drug was maintained.

Original language	English (US)
Pages (from-to)	13757-13760
Number of pages	4
Journal	Chemical Communications
Volume	50
Issue number	89
DOIs	https://doi.org/10.1039/c4cc06340f
State	Published - Oct 14 2014
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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title = "Esterase-activated release of naproxen from supramolecular nanofibres",

abstract = "Nanofibre forming peptide amphiphiles were conjugated to naproxen through an esterase-sensitive linker. The amount of naproxen released, in the presence of enzymes, was influenced by the linker conjugating the drug to the supramolecular assembly. In vitro studies showed the anti-inflammatory activity of the released drug was maintained.",

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AB - Nanofibre forming peptide amphiphiles were conjugated to naproxen through an esterase-sensitive linker. The amount of naproxen released, in the presence of enzymes, was influenced by the linker conjugating the drug to the supramolecular assembly. In vitro studies showed the anti-inflammatory activity of the released drug was maintained.

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Esterase-activated release of naproxen from supramolecular nanofibres

Abstract

ASJC Scopus subject areas

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