Estimating the Molecular Information Through Cell Signal Transduction Pathways

Zahmeeth Sakkaff, Aditya Immaneni, Massimilano Pierobon

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

The development of reliable abstractions, models, and characterizations of biochemical communication channels that propagate information from/to biological cells is one of the first challenges for the engineering of systems able to pervasively interface, control, and communicate through these channels, i.e., the Internet of Bio-N ano Things. Signal transduction pathways in eukaryotic cells are important examples of these channels, especially since their performance is directly linked to organisms' health, such as in cancer. In this paper, a novel computational approach is proposed to characterize the communication performance of signal transduction pathways based on chemical stochastic simulation tools, and the estimation of information-theoretic parameters from sample distributions. Differently from previous literature, this approach does not have constraints on the size of the data, accounts for the information contained in the dynamic pathway evolution, and estimates not only the end-to-end information propagation, but also the information through each component of the pathway. Numerical examples are provided as a case study focused on the popular JAK-STAT pathway, linked to immunodeficiency and cancer.

Original languageEnglish (US)
Title of host publication2018 IEEE 19th International Workshop on Signal Processing Advances in Wireless Communications, SPAWC 2018
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Print)9781538635124
DOIs
StatePublished - Aug 24 2018
Event19th IEEE International Workshop on Signal Processing Advances in Wireless Communications, SPAWC 2018 - Kalamata, Greece
Duration: Jun 25 2018Jun 28 2018

Publication series

NameIEEE Workshop on Signal Processing Advances in Wireless Communications, SPAWC
Volume2018-June

Other

Other19th IEEE International Workshop on Signal Processing Advances in Wireless Communications, SPAWC 2018
CountryGreece
CityKalamata
Period6/25/186/28/18

Keywords

  • Cell Signal Transduction Pathways
  • Gillespie Stochastic Simulation
  • Information Theory
  • Internet of Bio-N ano Things
  • Molecular Communication
  • N anonetworks

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Computer Science Applications
  • Information Systems

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