Often, biomedical researchers take a tissue sample from a tumour that unintentionally contains tumour cells and stromal cells so that gene expression from the sample represents two distinct kinds of cells. This is tolerated because techniques for separating tumour and stromal cells are expensive and time-consuming and the act of separation can alter gene expression. So, it is desirable to have a technique for estimating the proportion of tumour cells in a mixed sample to improve detection of differential expression in cancer cells.
- Gene expression
- Mixed sample
ASJC Scopus subject areas
- Statistics and Probability
- Statistics, Probability and Uncertainty