TY - JOUR
T1 - Eukaryotic transcriptional regulatory complexes
T2 - Cooperativity from near and afar
AU - Ogata, Kazuhiro
AU - Sato, Ko
AU - Tahirov, Tahir
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2003/2/1
Y1 - 2003/2/1
N2 - It is characteristic of eukaryotic transcription that a unique combination of multiple transcriptional regulatory proteins bound to promoter DNA specifically activate or repress downstream target genes; this is referred to as combinatorial gene regulation. Recently determined structures have revealed different modes of protein-protein interaction on the promoter DNA from near (e.g. the Runx1-CBFβ-DNA, NFAT-Fos-Jun-DNA, GABPα-GABPβ-DNA, Ets-1-Pax-5-DNA and PU.1-IRF-4-DNA complexes) and afar with DNA looping (e.g. the c-Myb-C/EBPβ-DNA complex), and their regulatory mechanisms.
AB - It is characteristic of eukaryotic transcription that a unique combination of multiple transcriptional regulatory proteins bound to promoter DNA specifically activate or repress downstream target genes; this is referred to as combinatorial gene regulation. Recently determined structures have revealed different modes of protein-protein interaction on the promoter DNA from near (e.g. the Runx1-CBFβ-DNA, NFAT-Fos-Jun-DNA, GABPα-GABPβ-DNA, Ets-1-Pax-5-DNA and PU.1-IRF-4-DNA complexes) and afar with DNA looping (e.g. the c-Myb-C/EBPβ-DNA complex), and their regulatory mechanisms.
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U2 - 10.1016/S0959-440X(03)00012-5
DO - 10.1016/S0959-440X(03)00012-5
M3 - Review article
C2 - 12581658
AN - SCOPUS:0037311664
SN - 0959-440X
VL - 13
SP - 40
EP - 48
JO - Current Opinion in Structural Biology
JF - Current Opinion in Structural Biology
IS - 1
ER -