Eukaryotic transcriptional regulatory complexes: Cooperativity from near and afar

Kazuhiro Ogata, Ko Sato, Tahir Tahirov

Research output: Contribution to journalReview article

82 Scopus citations

Abstract

It is characteristic of eukaryotic transcription that a unique combination of multiple transcriptional regulatory proteins bound to promoter DNA specifically activate or repress downstream target genes; this is referred to as combinatorial gene regulation. Recently determined structures have revealed different modes of protein-protein interaction on the promoter DNA from near (e.g. the Runx1-CBFβ-DNA, NFAT-Fos-Jun-DNA, GABPα-GABPβ-DNA, Ets-1-Pax-5-DNA and PU.1-IRF-4-DNA complexes) and afar with DNA looping (e.g. the c-Myb-C/EBPβ-DNA complex), and their regulatory mechanisms.

Original languageEnglish (US)
Pages (from-to)40-48
Number of pages9
JournalCurrent Opinion in Structural Biology
Volume13
Issue number1
DOIs
StatePublished - Feb 1 2003

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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