TY - JOUR
T1 - Evaluation of a sustained-release theophylline tablet in Young asthmatics
AU - Swigart, Scott A.
AU - Kobayashi, Roger H.
AU - Baldwin, Jeffrey N.
N1 - Funding Information:
We wish to acknowledge the staff of Children's Memorial Hospital for their valuable assistance and Ai Lan D. Kobayashi, M.D., Clarence Ueda, Ph.D., and Carol R. Angle, M.D., for their critical review. This work was supported in part by Mead Johnson Pharmaceutical Division and the Pediatric Immunology Research Fund, the University of Nebraska.
PY - 1985
Y1 - 1985
N2 - A sustained-release theophylline (SRT) tablet was evaluated in 15 children with moderately severe asthma between the ages of 3 and 5 years (4.2 ± 0.83 years). They received a mean daily dose of 20.4 mg/kg given q12h for 3 or more weeks with daily symptom scores and twice daily peak flow rates (PFR) measured. Serum theophylline levels (STL) were then obtained at 0, 1, 2, 4, 6, 8, 10, and 12 hr (eight children had 24-hr samples obtained), along with PFRs every 3 hr. The mean peak STL (x ± SD) was 16.6 ± 4.4 and the trough was 5.9 ± 2.8, with a peak-trough difference of 10.6 ± 3.9. The average time to peak level was 3.9 hr. The mean ±SD clearance was 1.42 ± 0.63 ml/kg per min and the apparent T1/2 was 5.11 ± 1.34 hr. The average weekly morning PFR for the 3-week period ranged from 116.8 ± 41.2 to 127.4 ± 37.4 L/min, and the evening PFT ranged from 126.5 ± 38.4 to 137.0 ± 40.9 L/min. In conclusion, the SRT tablet is effective in treating many young asthmatics on a 12-hr dosage schedule. For some children who experience excessive peak-trough differences, an 8-hr dosage schedule may be indicated.
AB - A sustained-release theophylline (SRT) tablet was evaluated in 15 children with moderately severe asthma between the ages of 3 and 5 years (4.2 ± 0.83 years). They received a mean daily dose of 20.4 mg/kg given q12h for 3 or more weeks with daily symptom scores and twice daily peak flow rates (PFR) measured. Serum theophylline levels (STL) were then obtained at 0, 1, 2, 4, 6, 8, 10, and 12 hr (eight children had 24-hr samples obtained), along with PFRs every 3 hr. The mean peak STL (x ± SD) was 16.6 ± 4.4 and the trough was 5.9 ± 2.8, with a peak-trough difference of 10.6 ± 3.9. The average time to peak level was 3.9 hr. The mean ±SD clearance was 1.42 ± 0.63 ml/kg per min and the apparent T1/2 was 5.11 ± 1.34 hr. The average weekly morning PFR for the 3-week period ranged from 116.8 ± 41.2 to 127.4 ± 37.4 L/min, and the evening PFT ranged from 126.5 ± 38.4 to 137.0 ± 40.9 L/min. In conclusion, the SRT tablet is effective in treating many young asthmatics on a 12-hr dosage schedule. For some children who experience excessive peak-trough differences, an 8-hr dosage schedule may be indicated.
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U2 - 10.3109/02770908509073143
DO - 10.3109/02770908509073143
M3 - Article
C2 - 4044473
AN - SCOPUS:0022004989
SN - 0277-0903
VL - 22
SP - 195
EP - 202
JO - Journal of Asthma
JF - Journal of Asthma
IS - 4
ER -