Evaluation of peritoneal microbubble oxygenation therapy in a rabbit model of hypoxemia

Nathan D. Legband, Jameel A. Feshitan, Mark A. Borden, Benjamin S. Terry

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Alternative extrapulmonary oxygenation technologies are needed to treat patients suffering from severe hypoxemia refractory to mechanical ventilation. We previously demonstrated that peritoneal microbubble oxygenation (PMO), in which phospholipid-coated oxygen microbubbles (OMBs) are delivered into the peritoneal cavity, can successfully oxygenate rats suffering from a right pneumothorax. This study addressed the need to scale up the procedure to a larger animal with a splanchnic cardiac output similar to humans. Our results show that PMO therapy can double the survival time of rabbits experiencing complete tracheal occlusion from 6.6 \pm 0.6 min for the saline controls to 12.2 \pm 3.0 min for the bolus PMO-treated cohort. Additionally, we designed and tested a new peritoneal delivery system to circulate OMBs through the peritoneal cavity. Circulation achieved a similar survival benefit to bolus delivery under these conditions. Overall, these results support the feasibility of the PMO technology to provide extrapulmonary ventilation for rescue of severely hypoxic patients.

Original languageEnglish (US)
Article number7001576
Pages (from-to)1376-1382
Number of pages7
JournalIEEE Transactions on Biomedical Engineering
Issue number5
StatePublished - May 1 2015


  • acute lung injury (ALI)
  • acute respiratory distress syndrome (ARDS)
  • airway obstruction
  • extrapulmonary ventilation
  • oxygen delivery

ASJC Scopus subject areas

  • Biomedical Engineering


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