Event-related potentials in cocaine-exposed children during a Stroop task

Linda C. Mayes; Dennis L. Molfese; Alexandra P.F. Key; Nicole C. Hunter

doi:10.1016/j.ntt.2005.05.011

Event-related potentials in cocaine-exposed children during a Stroop task

Linda C. Mayes, Dennis L. Molfese, Alexandra P.F. Key, Nicole C. Hunter

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Abstract

Objective: Prenatal cocaine-exposure may interfere with the ontogeny of prefrontal cortical executive functions due to cocaine's effect on the developing monoaminergic system. This study presents findings regarding cortical functioning in 29 prenatally cocaine-exposed (CE) and non-drug-exposed (NDE) 7- to 9-year-old children participating in event related potential (ERP) studies. Methods: ERPs were recorded using 128-electrode high-density arrays while children responded to a standard Stroop paradigm. Results: In the Stroop paradigm, CE children generated prolonged responses to the words while the NDE children produced briefer responses. Effects were noted in the region of the initial positive peak (P1), the second negative peak (N2) and the later positive peak (P3). Conclusions: Early cocaine exposure may inhibit the specialization and streamlining of brain region involvement during cognitive processing such that task processing is slower to begin, requires more diverse cortical involvement, and requires more time to complete. ERP methodology has considerable potential for studying frontal maturation and may provide additional information to clarify generally the specific effects of prenatal CE on cortical functioning and the developmental course of cognitive functions.

Original language	English (US)
Pages (from-to)	797-813
Number of pages	17
Journal	Neurotoxicology and Teratology
Volume	27
Issue number	6
DOIs	https://doi.org/10.1016/j.ntt.2005.05.011
State	Published - Nov 2005
Externally published	Yes

Keywords

Cortical maturation
Event-related potential
Prenatal cocaine exposure

ASJC Scopus subject areas

Toxicology
Developmental Neuroscience
Cellular and Molecular Neuroscience

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10.1016/j.ntt.2005.05.011

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@article{18be5b2eb40644158369b3a760560232,

title = "Event-related potentials in cocaine-exposed children during a Stroop task",

abstract = "Objective: Prenatal cocaine-exposure may interfere with the ontogeny of prefrontal cortical executive functions due to cocaine's effect on the developing monoaminergic system. This study presents findings regarding cortical functioning in 29 prenatally cocaine-exposed (CE) and non-drug-exposed (NDE) 7- to 9-year-old children participating in event related potential (ERP) studies. Methods: ERPs were recorded using 128-electrode high-density arrays while children responded to a standard Stroop paradigm. Results: In the Stroop paradigm, CE children generated prolonged responses to the words while the NDE children produced briefer responses. Effects were noted in the region of the initial positive peak (P1), the second negative peak (N2) and the later positive peak (P3). Conclusions: Early cocaine exposure may inhibit the specialization and streamlining of brain region involvement during cognitive processing such that task processing is slower to begin, requires more diverse cortical involvement, and requires more time to complete. ERP methodology has considerable potential for studying frontal maturation and may provide additional information to clarify generally the specific effects of prenatal CE on cortical functioning and the developmental course of cognitive functions.",

keywords = "Cortical maturation, Event-related potential, Prenatal cocaine exposure",

author = "Mayes, {Linda C.} and Molfese, {Dennis L.} and Key, {Alexandra P.F.} and Hunter, {Nicole C.}",

note = "Funding Information: This work was supported by several agencies that included NIDA grants RO1-DA-06025 (LCM), RO1 DADA017863 (LCM) and KO2-DA00222 (LCM) and grants from NICHD P01-HD03008 and NICHD R01HD17860, as well as DOE R215K000023 and HHS 90XA0011. Additionally, the work was supported in part by the Yale Children's Clinical Research Center grant MO1-RR06022, General Clinical Research Centers Program, National Center for Research Resources, NIH. The authors gratefully acknowledge the database management support of Ireneusz Sielski and our close collaboration with Dr. Richard Schottenfeld and his substance abuse treatment programs for pregnant cocaine-using women. Many of the women in our studies were active participants in his studies and much of our information regarding their perinatal drug use was obtained through our collaboration with Dr. Schottenfeld. The authors also gratefully acknowledge the assistance of Natalie Cunningham, Eva Ratajczak, and Jamie Wilson who assisted in the ERP data collection sessions, whose efforts were instrumental in helping the children feel comfortable in the sessions. ",

year = "2005",

month = nov,

doi = "10.1016/j.ntt.2005.05.011",

language = "English (US)",

volume = "27",

pages = "797--813",

journal = "Neurotoxicology and Teratology",

issn = "0892-0362",

publisher = "Elsevier Inc.",

number = "6",

}

TY - JOUR

T1 - Event-related potentials in cocaine-exposed children during a Stroop task

AU - Mayes, Linda C.

AU - Molfese, Dennis L.

AU - Key, Alexandra P.F.

AU - Hunter, Nicole C.

N1 - Funding Information: This work was supported by several agencies that included NIDA grants RO1-DA-06025 (LCM), RO1 DADA017863 (LCM) and KO2-DA00222 (LCM) and grants from NICHD P01-HD03008 and NICHD R01HD17860, as well as DOE R215K000023 and HHS 90XA0011. Additionally, the work was supported in part by the Yale Children's Clinical Research Center grant MO1-RR06022, General Clinical Research Centers Program, National Center for Research Resources, NIH. The authors gratefully acknowledge the database management support of Ireneusz Sielski and our close collaboration with Dr. Richard Schottenfeld and his substance abuse treatment programs for pregnant cocaine-using women. Many of the women in our studies were active participants in his studies and much of our information regarding their perinatal drug use was obtained through our collaboration with Dr. Schottenfeld. The authors also gratefully acknowledge the assistance of Natalie Cunningham, Eva Ratajczak, and Jamie Wilson who assisted in the ERP data collection sessions, whose efforts were instrumental in helping the children feel comfortable in the sessions.

PY - 2005/11

Y1 - 2005/11

N2 - Objective: Prenatal cocaine-exposure may interfere with the ontogeny of prefrontal cortical executive functions due to cocaine's effect on the developing monoaminergic system. This study presents findings regarding cortical functioning in 29 prenatally cocaine-exposed (CE) and non-drug-exposed (NDE) 7- to 9-year-old children participating in event related potential (ERP) studies. Methods: ERPs were recorded using 128-electrode high-density arrays while children responded to a standard Stroop paradigm. Results: In the Stroop paradigm, CE children generated prolonged responses to the words while the NDE children produced briefer responses. Effects were noted in the region of the initial positive peak (P1), the second negative peak (N2) and the later positive peak (P3). Conclusions: Early cocaine exposure may inhibit the specialization and streamlining of brain region involvement during cognitive processing such that task processing is slower to begin, requires more diverse cortical involvement, and requires more time to complete. ERP methodology has considerable potential for studying frontal maturation and may provide additional information to clarify generally the specific effects of prenatal CE on cortical functioning and the developmental course of cognitive functions.

AB - Objective: Prenatal cocaine-exposure may interfere with the ontogeny of prefrontal cortical executive functions due to cocaine's effect on the developing monoaminergic system. This study presents findings regarding cortical functioning in 29 prenatally cocaine-exposed (CE) and non-drug-exposed (NDE) 7- to 9-year-old children participating in event related potential (ERP) studies. Methods: ERPs were recorded using 128-electrode high-density arrays while children responded to a standard Stroop paradigm. Results: In the Stroop paradigm, CE children generated prolonged responses to the words while the NDE children produced briefer responses. Effects were noted in the region of the initial positive peak (P1), the second negative peak (N2) and the later positive peak (P3). Conclusions: Early cocaine exposure may inhibit the specialization and streamlining of brain region involvement during cognitive processing such that task processing is slower to begin, requires more diverse cortical involvement, and requires more time to complete. ERP methodology has considerable potential for studying frontal maturation and may provide additional information to clarify generally the specific effects of prenatal CE on cortical functioning and the developmental course of cognitive functions.

KW - Cortical maturation

KW - Event-related potential

KW - Prenatal cocaine exposure

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SN - 0892-0362

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EP - 813

JO - Neurotoxicology and Teratology

JF - Neurotoxicology and Teratology

IS - 6

ER -

Event-related potentials in cocaine-exposed children during a Stroop task

Abstract

Keywords

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