Evidence for a novel gene associated with low tumor metastatic potential

Patricia S. Steeg, Generoso Bevilacqua, Laszlo Kopper, Unnur P. Thorgeirsson, James E. Talmadge, Lance A. Liotta, Mark E. Sobel

Research output: Contribution to journalArticlepeer-review

1347 Scopus citations


We describe a gene, NM23, that is associated with the tumor metastatic process. NM23 RNA levels were highest in cells and tumors of relatively low metastatic potential in two experimental systems: (1) murine K-1735 melanoma cell lines, in which the gene was identifiede, and (2) N-nitroso-N-methylurea-induced rat mammary earcinomas. NM23 RNA levels did not correlate with cell sensitivity to host immunological responses and may, therefore, be associated with intrinsle aggressiveness. The predicted carboxy-terminal protein seaquence encoded by the pNM23 cDNA clone is nove compared with Genebank animal, bacterial, and viral sequences.[J Natl Cancer Inst 1988;80:200-204]

Original languageEnglish (US)
Pages (from-to)200-204
Number of pages5
JournalJournal of the National Cancer Institute
Issue number3
StatePublished - Apr 6 1988
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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