Evidence for a novel gene associated with low tumor metastatic potential

Patricia S. Steeg; Generoso Bevilacqua; Laszlo Kopper; Unnur P. Thorgeirsson; James E. Talmadge; Lance A. Liotta; Mark E. Sobel

doi:10.1093/jnci/80.3.200

Evidence for a novel gene associated with low tumor metastatic potential

Patricia S. Steeg, Generoso Bevilacqua, Laszlo Kopper, Unnur P. Thorgeirsson, James E. Talmadge, Lance A. Liotta, Mark E. Sobel

Research output: Contribution to journal › Article › peer-review

1253 Scopus citations

Abstract

We describe a gene, NM23, that is associated with the tumor metastatic process. NM23 RNA levels were highest in cells and tumors of relatively low metastatic potential in two experimental systems: (1) murine K-1735 melanoma cell lines, in which the gene was identifiede, and (2) N-nitroso-N-methylurea-induced rat mammary earcinomas. NM23 RNA levels did not correlate with cell sensitivity to host immunological responses and may, therefore, be associated with intrinsle aggressiveness. The predicted carboxy-terminal protein seaquence encoded by the pNM23 cDNA clone is nove compared with Genebank animal, bacterial, and viral sequences.[J Natl Cancer Inst 1988;80:200-204]

Original language	English (US)
Pages (from-to)	200-204
Number of pages	5
Journal	Journal of the National Cancer Institute
Volume	80
Issue number	3
DOIs	https://doi.org/10.1093/jnci/80.3.200
State	Published - Apr 6 1988
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

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title = "Evidence for a novel gene associated with low tumor metastatic potential",

abstract = "We describe a gene, NM23, that is associated with the tumor metastatic process. NM23 RNA levels were highest in cells and tumors of relatively low metastatic potential in two experimental systems: (1) murine K-1735 melanoma cell lines, in which the gene was identifiede, and (2) N-nitroso-N-methylurea-induced rat mammary earcinomas. NM23 RNA levels did not correlate with cell sensitivity to host immunological responses and may, therefore, be associated with intrinsle aggressiveness. The predicted carboxy-terminal protein seaquence encoded by the pNM23 cDNA clone is nove compared with Genebank animal, bacterial, and viral sequences.[J Natl Cancer Inst 1988;80:200-204]",

author = "Steeg, {Patricia S.} and Generoso Bevilacqua and Laszlo Kopper and Thorgeirsson, {Unnur P.} and Talmadge, {James E.} and Liotta, {Lance A.} and Sobel, {Mark E.}",

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T1 - Evidence for a novel gene associated with low tumor metastatic potential

AU - Steeg, Patricia S.

AU - Bevilacqua, Generoso

AU - Kopper, Laszlo

AU - Thorgeirsson, Unnur P.

AU - Talmadge, James E.

AU - Liotta, Lance A.

AU - Sobel, Mark E.

PY - 1988/4/6

Y1 - 1988/4/6

N2 - We describe a gene, NM23, that is associated with the tumor metastatic process. NM23 RNA levels were highest in cells and tumors of relatively low metastatic potential in two experimental systems: (1) murine K-1735 melanoma cell lines, in which the gene was identifiede, and (2) N-nitroso-N-methylurea-induced rat mammary earcinomas. NM23 RNA levels did not correlate with cell sensitivity to host immunological responses and may, therefore, be associated with intrinsle aggressiveness. The predicted carboxy-terminal protein seaquence encoded by the pNM23 cDNA clone is nove compared with Genebank animal, bacterial, and viral sequences.[J Natl Cancer Inst 1988;80:200-204]

AB - We describe a gene, NM23, that is associated with the tumor metastatic process. NM23 RNA levels were highest in cells and tumors of relatively low metastatic potential in two experimental systems: (1) murine K-1735 melanoma cell lines, in which the gene was identifiede, and (2) N-nitroso-N-methylurea-induced rat mammary earcinomas. NM23 RNA levels did not correlate with cell sensitivity to host immunological responses and may, therefore, be associated with intrinsle aggressiveness. The predicted carboxy-terminal protein seaquence encoded by the pNM23 cDNA clone is nove compared with Genebank animal, bacterial, and viral sequences.[J Natl Cancer Inst 1988;80:200-204]

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