TY - JOUR
T1 - Evidence for a novel gene associated with low tumor metastatic potential
AU - Steeg, Patricia S.
AU - Bevilacqua, Generoso
AU - Kopper, Laszlo
AU - Thorgeirsson, Unnur P.
AU - Talmadge, James E.
AU - Liotta, Lance A.
AU - Sobel, Mark E.
PY - 1988/4/6
Y1 - 1988/4/6
N2 - We describe a gene, NM23, that is associated with the tumor metastatic process. NM23 RNA levels were highest in cells and tumors of relatively low metastatic potential in two experimental systems: (1) murine K-1735 melanoma cell lines, in which the gene was identifiede, and (2) N-nitroso-N-methylurea-induced rat mammary earcinomas. NM23 RNA levels did not correlate with cell sensitivity to host immunological responses and may, therefore, be associated with intrinsle aggressiveness. The predicted carboxy-terminal protein seaquence encoded by the pNM23 cDNA clone is nove compared with Genebank animal, bacterial, and viral sequences.[J Natl Cancer Inst 1988;80:200-204]
AB - We describe a gene, NM23, that is associated with the tumor metastatic process. NM23 RNA levels were highest in cells and tumors of relatively low metastatic potential in two experimental systems: (1) murine K-1735 melanoma cell lines, in which the gene was identifiede, and (2) N-nitroso-N-methylurea-induced rat mammary earcinomas. NM23 RNA levels did not correlate with cell sensitivity to host immunological responses and may, therefore, be associated with intrinsle aggressiveness. The predicted carboxy-terminal protein seaquence encoded by the pNM23 cDNA clone is nove compared with Genebank animal, bacterial, and viral sequences.[J Natl Cancer Inst 1988;80:200-204]
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U2 - 10.1093/jnci/80.3.200
DO - 10.1093/jnci/80.3.200
M3 - Article
C2 - 3346912
AN - SCOPUS:0023937268
VL - 80
SP - 200
EP - 204
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
SN - 0027-8874
IS - 3
ER -