TY - JOUR
T1 - Evidence for a novel gene associated with low tumor metastatic potential
AU - Steeg, Patricia S.
AU - Bevilacqua, Generoso
AU - Kopper, Laszlo
AU - Thorgeirsson, Unnur P.
AU - Talmadge, James E.
AU - Liotta, Lance A.
AU - Sobel, Mark E.
N1 - Funding Information:
2P. S. Steeg was a fellow of the Jane Coffin Childs Memorial Fund for Medical Research. This investigation was aided by a grant from the Jane Coffin Childs Memorial Fund for Medical Research and by Public Health Service postdoctoral fellowship HD-06423 from the National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services. L. Kopper was funded by an American Cancer Society— Eleanor Roosevelt—International Cancer Fellowship awarded by the International Union Against Cancer. G. Bevilacqua was a fellow of the Italian Association for Cancer Research. 'Laboratory of Pathology, Division of Cancer Biology and Diagnosis, National Cancer Institute, Bethesda, MD 20892.
PY - 1988/4/6
Y1 - 1988/4/6
N2 - We describe a gene, NM23, that is associated with the tumor metastatic process. NM23 RNA levels were highest in cells and tumors of relatively low metastatic potential in two experimental systems: (1) murine K-1735 melanoma cell lines, in which the gene was identifiede, and (2) N-nitroso-N-methylurea-induced rat mammary earcinomas. NM23 RNA levels did not correlate with cell sensitivity to host immunological responses and may, therefore, be associated with intrinsle aggressiveness. The predicted carboxy-terminal protein seaquence encoded by the pNM23 cDNA clone is nove compared with Genebank animal, bacterial, and viral sequences.[J Natl Cancer Inst 1988;80:200-204]
AB - We describe a gene, NM23, that is associated with the tumor metastatic process. NM23 RNA levels were highest in cells and tumors of relatively low metastatic potential in two experimental systems: (1) murine K-1735 melanoma cell lines, in which the gene was identifiede, and (2) N-nitroso-N-methylurea-induced rat mammary earcinomas. NM23 RNA levels did not correlate with cell sensitivity to host immunological responses and may, therefore, be associated with intrinsle aggressiveness. The predicted carboxy-terminal protein seaquence encoded by the pNM23 cDNA clone is nove compared with Genebank animal, bacterial, and viral sequences.[J Natl Cancer Inst 1988;80:200-204]
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U2 - 10.1093/jnci/80.3.200
DO - 10.1093/jnci/80.3.200
M3 - Article
C2 - 3346912
AN - SCOPUS:0023937268
VL - 80
SP - 200
EP - 204
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
SN - 0027-8874
IS - 3
ER -