Evidence for extrinsic exonucleolytic proofreading

Stephanie A. Nick McElhinny, Youri I. Pavlov, Thomas A. Kunkel

Research output: Contribution to journalReview articlepeer-review

32 Scopus citations

Abstract

Exonucleolytic proofreading of DNA synthesis errors is one of the major determinants of genome stability. However, many DNA transactions that contribute to genome stability require synthesis by polymerases that naturally lack intrinsic 3′ exonuclease activity and some of which are highly inaccurate. Here we discuss evidence that errors made by these polymerases may be edited by a separate 3′ exonuclease, and we consider how such extrinsic proofreading may differ from proofreading by exonucleases that are intrinsic to replicative DNA polymerases.

Original languageEnglish (US)
Pages (from-to)958-962
Number of pages5
JournalCell Cycle
Volume5
Issue number9
DOIs
StatePublished - May 1 2006

Keywords

  • Base substitutions
  • DNA polymerase
  • DNA repair
  • DNA replication fidelity
  • Exonuclease
  • Mutagenesis
  • Proofreading

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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