Evidence for the clonal origin of spontaneous metastases

James E. Talmadge; Sandra R. Wolman; Isaiah J. Fidler

doi:10.1126/science.6953592

Evidence for the clonal origin of spontaneous metastases

James E. Talmadge, Sandra R. Wolman, Isaiah J. Fidler

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241 Scopus citations

Abstract

A cultured cell line of the K-1735 melanoma was x-irradiated to induce chromosome breakage and rearrangements and then was implanted into the footpads of syngenic C3H mice. Spontaneous lung metastases were isolated from different animals, established in culture as individual lines, and then karyotyped. Within certain metastases, the same chromosomal abnormality (or abnormalities) (recombinant chromosomes) was found in all the cells examined. Most metastases differed from one another in that they exhibited characteristic combinations of chromosomal markers. These findings indicated that the metastases were clonal and that they probably originated from different progenitor cells.

Original language	English (US)
Pages (from-to)	361-363
Number of pages	3
Journal	Science
Volume	217
Issue number	4557
DOIs	https://doi.org/10.1126/science.6953592
State	Published - 1982
Externally published	Yes

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title = "Evidence for the clonal origin of spontaneous metastases",

abstract = "A cultured cell line of the K-1735 melanoma was x-irradiated to induce chromosome breakage and rearrangements and then was implanted into the footpads of syngenic C3H mice. Spontaneous lung metastases were isolated from different animals, established in culture as individual lines, and then karyotyped. Within certain metastases, the same chromosomal abnormality (or abnormalities) (recombinant chromosomes) was found in all the cells examined. Most metastases differed from one another in that they exhibited characteristic combinations of chromosomal markers. These findings indicated that the metastases were clonal and that they probably originated from different progenitor cells.",

author = "Talmadge, {James E.} and Wolman, {Sandra R.} and Fidler, {Isaiah J.}",

year = "1982",

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pages = "361--363",

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T1 - Evidence for the clonal origin of spontaneous metastases

AU - Talmadge, James E.

AU - Wolman, Sandra R.

AU - Fidler, Isaiah J.

PY - 1982

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N2 - A cultured cell line of the K-1735 melanoma was x-irradiated to induce chromosome breakage and rearrangements and then was implanted into the footpads of syngenic C3H mice. Spontaneous lung metastases were isolated from different animals, established in culture as individual lines, and then karyotyped. Within certain metastases, the same chromosomal abnormality (or abnormalities) (recombinant chromosomes) was found in all the cells examined. Most metastases differed from one another in that they exhibited characteristic combinations of chromosomal markers. These findings indicated that the metastases were clonal and that they probably originated from different progenitor cells.

AB - A cultured cell line of the K-1735 melanoma was x-irradiated to induce chromosome breakage and rearrangements and then was implanted into the footpads of syngenic C3H mice. Spontaneous lung metastases were isolated from different animals, established in culture as individual lines, and then karyotyped. Within certain metastases, the same chromosomal abnormality (or abnormalities) (recombinant chromosomes) was found in all the cells examined. Most metastases differed from one another in that they exhibited characteristic combinations of chromosomal markers. These findings indicated that the metastases were clonal and that they probably originated from different progenitor cells.

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JF - Science

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Evidence for the clonal origin of spontaneous metastases

Abstract

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