Evidence for the conversion of angiotensin I to angiotensin II by the coronary microcirculation

Kurtis G. Cornish; William L. Joyner; Joseph P. Gilmore

doi:10.1159/000158211

Evidence for the conversion of angiotensin I to angiotensin II by the coronary microcirculation

Kurtis G. Cornish, William L. Joyner, Joseph P. Gilmore

Cellular & Integrative Physiology

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Cardiac tissue from hamster neonates was transplanted into the hamster cheek pouch. After vascularization of the transplanted tissue the vessels were tested for their ability to convert angiotensin I (A_I) to angiotensin II (A_II)-AI caused vasoconstriction of the coronary vessels which was reduced significantly by converting enzyme inhibitor and the An antagonist (Sar¹-Ala⁸) angiotensin II. It was concluded that the vessels of transplanted cardiac allografts convert A_Ito A_IIin a manner similar to that observed in the whole heart indicating that this procedure provides a good model for studying the microcirculation of the heart.

Original language	English (US)
Pages (from-to)	241-246
Number of pages	6
Journal	Journal of Vascular Research
Volume	16
Issue number	5
DOIs	https://doi.org/10.1159/000158211
State	Published - 1979

Keywords

Angiotensin I
Angiotensin II
Angiotensin conversion
Cardiac allografts
Converting enzyme inhibitor
Coronary circulation
Hamster
Saralasin

ASJC Scopus subject areas

Physiology
Cardiology and Cardiovascular Medicine

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10.1159/000158211

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title = "Evidence for the conversion of angiotensin I to angiotensin II by the coronary microcirculation",

abstract = "Cardiac tissue from hamster neonates was transplanted into the hamster cheek pouch. After vascularization of the transplanted tissue the vessels were tested for their ability to convert angiotensin I (AI) to angiotensin II (AII)-AI caused vasoconstriction of the coronary vessels which was reduced significantly by converting enzyme inhibitor and the An antagonist (Sar1-Ala8) angiotensin II. It was concluded that the vessels of transplanted cardiac allografts convert AIto AIIin a manner similar to that observed in the whole heart indicating that this procedure provides a good model for studying the microcirculation of the heart.",

keywords = "Angiotensin I, Angiotensin II, Angiotensin conversion, Cardiac allografts, Converting enzyme inhibitor, Coronary circulation, Hamster, Saralasin",

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AU - Cornish, Kurtis G.

AU - Joyner, William L.

AU - Gilmore, Joseph P.

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N2 - Cardiac tissue from hamster neonates was transplanted into the hamster cheek pouch. After vascularization of the transplanted tissue the vessels were tested for their ability to convert angiotensin I (AI) to angiotensin II (AII)-AI caused vasoconstriction of the coronary vessels which was reduced significantly by converting enzyme inhibitor and the An antagonist (Sar1-Ala8) angiotensin II. It was concluded that the vessels of transplanted cardiac allografts convert AIto AIIin a manner similar to that observed in the whole heart indicating that this procedure provides a good model for studying the microcirculation of the heart.

AB - Cardiac tissue from hamster neonates was transplanted into the hamster cheek pouch. After vascularization of the transplanted tissue the vessels were tested for their ability to convert angiotensin I (AI) to angiotensin II (AII)-AI caused vasoconstriction of the coronary vessels which was reduced significantly by converting enzyme inhibitor and the An antagonist (Sar1-Ala8) angiotensin II. It was concluded that the vessels of transplanted cardiac allografts convert AIto AIIin a manner similar to that observed in the whole heart indicating that this procedure provides a good model for studying the microcirculation of the heart.

KW - Angiotensin I

KW - Angiotensin II

KW - Angiotensin conversion

KW - Cardiac allografts

KW - Converting enzyme inhibitor

KW - Coronary circulation

KW - Hamster

KW - Saralasin

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Evidence for the conversion of angiotensin I to angiotensin II by the coronary microcirculation

Abstract

Keywords

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