Evidence for the conversion of angiotensin I to angiotensin II by the coronary microcirculation

Kurtis G. Cornish, William L. Joyner, Joseph P. Gilmore

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Cardiac tissue from hamster neonates was transplanted into the hamster cheek pouch. After vascularization of the transplanted tissue the vessels were tested for their ability to convert angiotensin I (AI) to angiotensin II (AII)-AI caused vasoconstriction of the coronary vessels which was reduced significantly by converting enzyme inhibitor and the An antagonist (Sar1-Ala8) angiotensin II. It was concluded that the vessels of transplanted cardiac allografts convert AIto AIIin a manner similar to that observed in the whole heart indicating that this procedure provides a good model for studying the microcirculation of the heart.

Original languageEnglish (US)
Pages (from-to)241-246
Number of pages6
JournalJournal of Vascular Research
Volume16
Issue number5
DOIs
StatePublished - Jan 1 1979

Keywords

  • Angiotensin I
  • Angiotensin II
  • Angiotensin conversion
  • Cardiac allografts
  • Converting enzyme inhibitor
  • Coronary circulation
  • Hamster
  • Saralasin

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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