Evidence for the conversion of angiotensin I to angiotensin II by the coronary microcirculation

Kurtis G. Cornish, William L. Joyner, Joseph P. Gilmore

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Cardiac tissue from hamster neonates was transplanted into the hamster cheek pouch. After vascularization of the transplanted tissue the vessels were tested for their ability to convert angiotensin I (AI) to angiotensin II (AII)-AI caused vasoconstriction of the coronary vessels which was reduced significantly by converting enzyme inhibitor and the An antagonist (Sar1-Ala8) angiotensin II. It was concluded that the vessels of transplanted cardiac allografts convert AIto AIIin a manner similar to that observed in the whole heart indicating that this procedure provides a good model for studying the microcirculation of the heart.

Original languageEnglish (US)
Pages (from-to)241-246
Number of pages6
JournalJournal of Vascular Research
Issue number5
StatePublished - 1979
Externally publishedYes


  • Angiotensin I
  • Angiotensin II
  • Angiotensin conversion
  • Cardiac allografts
  • Converting enzyme inhibitor
  • Coronary circulation
  • Hamster
  • Saralasin

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine


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