Evidence for the replication of bovine leukemia virus in the B lymphocytes.

P. S. Paul; K. A. Pomeroy; D. W. Johnson; C. C. Muscoplat; B. S. Handwerger; F. F. Soper; D. K. Sorensen

Evidence for the replication of bovine leukemia virus in the B lymphocytes.

P. S. Paul, K. A. Pomeroy, D. W. Johnson, C. C. Muscoplat, B. S. Handwerger, F. F. Soper, D. K. Sorensen

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Abstract

Bovine peripheral blood lymphocytes from a cow with persistent lymphocytosis were separated on nylon wool columns into nylon-adherent and nonadherent populations. Nylon-adherent cells were highly enriched for surface immunoglobulin (SIg) bearing B lymphocytes (95.5%) and nonadherent cells for SIg negative non-B cells, presumably T lymphocytes (96.3%). The B lymphocytes were found to be the major producers for bovine leukemia virus. A total of 39% of the B-enriched cells, surviving after 72 hours in culture, produced bovine leukemia virus as compared with 0.5% of the non-B cells.

Original language	English (US)
Pages (from-to)	873-876
Number of pages	4
Journal	American journal of veterinary research
Volume	38
Issue number	6
State	Published - Jun 1977

ASJC Scopus subject areas

General Veterinary

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title = "Evidence for the replication of bovine leukemia virus in the B lymphocytes.",

abstract = "Bovine peripheral blood lymphocytes from a cow with persistent lymphocytosis were separated on nylon wool columns into nylon-adherent and nonadherent populations. Nylon-adherent cells were highly enriched for surface immunoglobulin (SIg) bearing B lymphocytes (95.5%) and nonadherent cells for SIg negative non-B cells, presumably T lymphocytes (96.3%). The B lymphocytes were found to be the major producers for bovine leukemia virus. A total of 39% of the B-enriched cells, surviving after 72 hours in culture, produced bovine leukemia virus as compared with 0.5% of the non-B cells.",

author = "Paul, {P. S.} and Pomeroy, {K. A.} and Johnson, {D. W.} and Muscoplat, {C. C.} and Handwerger, {B. S.} and Soper, {F. F.} and Sorensen, {D. K.}",

year = "1977",

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T1 - Evidence for the replication of bovine leukemia virus in the B lymphocytes.

AU - Paul, P. S.

AU - Pomeroy, K. A.

AU - Johnson, D. W.

AU - Muscoplat, C. C.

AU - Handwerger, B. S.

AU - Soper, F. F.

AU - Sorensen, D. K.

PY - 1977/6

Y1 - 1977/6

N2 - Bovine peripheral blood lymphocytes from a cow with persistent lymphocytosis were separated on nylon wool columns into nylon-adherent and nonadherent populations. Nylon-adherent cells were highly enriched for surface immunoglobulin (SIg) bearing B lymphocytes (95.5%) and nonadherent cells for SIg negative non-B cells, presumably T lymphocytes (96.3%). The B lymphocytes were found to be the major producers for bovine leukemia virus. A total of 39% of the B-enriched cells, surviving after 72 hours in culture, produced bovine leukemia virus as compared with 0.5% of the non-B cells.

AB - Bovine peripheral blood lymphocytes from a cow with persistent lymphocytosis were separated on nylon wool columns into nylon-adherent and nonadherent populations. Nylon-adherent cells were highly enriched for surface immunoglobulin (SIg) bearing B lymphocytes (95.5%) and nonadherent cells for SIg negative non-B cells, presumably T lymphocytes (96.3%). The B lymphocytes were found to be the major producers for bovine leukemia virus. A total of 39% of the B-enriched cells, surviving after 72 hours in culture, produced bovine leukemia virus as compared with 0.5% of the non-B cells.

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Evidence for the replication of bovine leukemia virus in the B lymphocytes.

Abstract

ASJC Scopus subject areas

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