TY - JOUR
T1 - Evidence that suppression of insulin secretion by insulin itself is neurally mediated
AU - Boden, Guenther
AU - Chen, Xinhua
AU - DeSantis, Richard
AU - Kolaczynski, Jerzy
AU - Morris, Michael
N1 - Funding Information:
From the Division of Endocrinology and Metabolism and the General Clinical Research Center, Temple University School of Medicine, Philadelphia; and the Department of Surgery, Albert Einstein Medical Center, Philadelphia; Philadelphia, PA. Submitted April 18,1992; accepted June 17, 1992. Supported by National Institutes of Health Grants No. ROl-AG-07988 (G.B.), MOI-RR-00349 (G eneral Clinical Research Center), and T32-DK-07162 (R.D.). Address reprint requests to Guenther Boden, MD, Temple University Hospital, 3401 NBroad St, Philadelphia, PA 19140. Copyright 0 1993 by WB. Saunders Company 0026-0495/93/4206-0021$03.00/0
PY - 1993/6
Y1 - 1993/6
N2 - We examined the mechanism by which an increase in blood insulin concentration inhibits insulin secretion by the pancreas. To this end, we determined plasma C-peptide concentrations during euglycemic-hyperinsulinemic (∼500 pmol/L) clamps in five patients with insulin-dependent diabetes mellitus (IDDM) after combined pancreas and kidney ( P K) transplantation, in five nondiabetic patients after kidney transplantation (K), and in six normal control subjects. Hyperinsulinemia decreased C-peptide concentrations in K patients (by 60%, P < .01) and controls (by 35%, P < .05), but not in P K patients (653 ± 115 v 702 ± 197 pmol/L before and after 4 hours of hyperinsulinemia, respectively). The main difference between K patients and controls and P K patients was that the pancreas in K patients and controls was innervated, whereas the transplanted pancreas of K P patients was denervated. The data therefore suggested that the inhibition of pancreatic insulin secretion by hyperinsulinemia was neurally mediated.
AB - We examined the mechanism by which an increase in blood insulin concentration inhibits insulin secretion by the pancreas. To this end, we determined plasma C-peptide concentrations during euglycemic-hyperinsulinemic (∼500 pmol/L) clamps in five patients with insulin-dependent diabetes mellitus (IDDM) after combined pancreas and kidney ( P K) transplantation, in five nondiabetic patients after kidney transplantation (K), and in six normal control subjects. Hyperinsulinemia decreased C-peptide concentrations in K patients (by 60%, P < .01) and controls (by 35%, P < .05), but not in P K patients (653 ± 115 v 702 ± 197 pmol/L before and after 4 hours of hyperinsulinemia, respectively). The main difference between K patients and controls and P K patients was that the pancreas in K patients and controls was innervated, whereas the transplanted pancreas of K P patients was denervated. The data therefore suggested that the inhibition of pancreatic insulin secretion by hyperinsulinemia was neurally mediated.
UR - http://www.scopus.com/inward/record.url?scp=0027321973&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027321973&partnerID=8YFLogxK
U2 - 10.1016/0026-0495(93)90250-R
DO - 10.1016/0026-0495(93)90250-R
M3 - Article
C2 - 8510525
AN - SCOPUS:0027321973
SN - 0026-0495
VL - 42
SP - 786
EP - 789
JO - Metabolism
JF - Metabolism
IS - 6
ER -