Ewing Sarcoma with 7;22 translocation: Three new cases and clinicopathological characterization

Sarah Catherine Shulman, Howard Katzenstein, Julia Bridge, Lucas L. Bannister, Muna Qayed, Shervin Oskouei, Bahig M. Shehata

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Ewing sarcoma (ES) is the second most common primary bone malignancy in children and is typically characterized by a translocation involving the EWS gene on chromosome 22 and a member of the ETS family of genes: FLI1 (90), ERG1 (5), ETV1 (1), ETV4 (1), and FEV (1). We identified three new cases of t(7;22) (p22;q12) (EWS-ETV1) ES and a literature search revealed an additional six cases. In comparison to conventional ES with t(11;22) (q24;q12) (EWS-FLI1), the t(7;22) ES variant has a higher propensity for females and children in a younger age group and it occurs more commonly in extraosseous locations.

Original languageEnglish (US)
Pages (from-to)341-348
Number of pages8
JournalFetal and Pediatric Pathology
Volume31
Issue number6
DOIs
StatePublished - Dec 2012

Keywords

  • Ewing sarcoma (ES)
  • T(7;22)
  • Translocation

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pathology and Forensic Medicine

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