Ewing Sarcoma with 7;22 translocation: Three new cases and clinicopathological characterization

Sarah Catherine Shulman; Howard Katzenstein; Julia Bridge; Lucas L. Bannister; Muna Qayed; Shervin Oskouei; Bahig M. Shehata

doi:10.3109/15513815.2012.659397

Ewing Sarcoma with 7;22 translocation: Three new cases and clinicopathological characterization

Sarah Catherine Shulman, Howard Katzenstein, Julia Bridge, Lucas L. Bannister, Muna Qayed, Shervin Oskouei, Bahig M. Shehata

Pathology & Microbiology

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Ewing sarcoma (ES) is the second most common primary bone malignancy in children and is typically characterized by a translocation involving the EWS gene on chromosome 22 and a member of the ETS family of genes: FLI1 (90), ERG1 (5), ETV1 (1), ETV4 (1), and FEV (1). We identified three new cases of t(7;22) (p22;q12) (EWS-ETV1) ES and a literature search revealed an additional six cases. In comparison to conventional ES with t(11;22) (q24;q12) (EWS-FLI1), the t(7;22) ES variant has a higher propensity for females and children in a younger age group and it occurs more commonly in extraosseous locations.

Original language	English (US)
Pages (from-to)	341-348
Number of pages	8
Journal	Fetal and Pediatric Pathology
Volume	31
Issue number	6
DOIs	https://doi.org/10.3109/15513815.2012.659397
State	Published - Dec 2012

Keywords

Ewing sarcoma (ES)
T(7;22)
Translocation

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Pathology and Forensic Medicine

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10.3109/15513815.2012.659397

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title = "Ewing Sarcoma with 7;22 translocation: Three new cases and clinicopathological characterization",

abstract = "Ewing sarcoma (ES) is the second most common primary bone malignancy in children and is typically characterized by a translocation involving the EWS gene on chromosome 22 and a member of the ETS family of genes: FLI1 (90), ERG1 (5), ETV1 (1), ETV4 (1), and FEV (1). We identified three new cases of t(7;22) (p22;q12) (EWS-ETV1) ES and a literature search revealed an additional six cases. In comparison to conventional ES with t(11;22) (q24;q12) (EWS-FLI1), the t(7;22) ES variant has a higher propensity for females and children in a younger age group and it occurs more commonly in extraosseous locations.",

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AU - Shulman, Sarah Catherine

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AU - Bridge, Julia

AU - Bannister, Lucas L.

AU - Qayed, Muna

AU - Oskouei, Shervin

AU - Shehata, Bahig M.

PY - 2012/12

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AB - Ewing sarcoma (ES) is the second most common primary bone malignancy in children and is typically characterized by a translocation involving the EWS gene on chromosome 22 and a member of the ETS family of genes: FLI1 (90), ERG1 (5), ETV1 (1), ETV4 (1), and FEV (1). We identified three new cases of t(7;22) (p22;q12) (EWS-ETV1) ES and a literature search revealed an additional six cases. In comparison to conventional ES with t(11;22) (q24;q12) (EWS-FLI1), the t(7;22) ES variant has a higher propensity for females and children in a younger age group and it occurs more commonly in extraosseous locations.

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KW - T(7;22)

KW - Translocation

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Ewing Sarcoma with 7;22 translocation: Three new cases and clinicopathological characterization

Abstract

Keywords

ASJC Scopus subject areas

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