Abstract
A reciprocal t(11;22)(q24;q12) is found in 85% of Ewing sarcomas (ES) cases. We report a case of a child with ES, in whom trisomy 8 was observed as the sole chromosomal abnormality. Fluorescence in situ hybridization - using a set of probes that localize to 22q12 (EWS) and 11q24 (FLI-1) and usually show the translocation as fusion (red-green) signal on der(22) - showed a fusion signal on der(11) suggesting an insertion as the mechanism that led to the EWS-FLI-1 gene rearrangement. Reverse transcriptase-polymerase chain reaction studies revealed the presence of two EWS/FLI1 fusion gene products.
Original language | English (US) |
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Pages (from-to) | 72-75 |
Number of pages | 4 |
Journal | Cancer genetics and cytogenetics |
Volume | 133 |
Issue number | 1 |
DOIs | |
State | Published - 2002 |
ASJC Scopus subject areas
- Molecular Biology
- Genetics
- Cancer Research