Ex vivo expanded hematopoietic stem cells for ischemia

Jingwei Lu, Reeva Aggarwal, Vincent J. Pompili, Hiranmoy Das

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Ischemia related diseases are on rise worldwide and have been shown to cause irreversible damage to the cells due to the blockage of blood supply to the tissue. Conventional therapies are less effective as they do not consider repair of the damaged tissues. Thus, alternative, stem cell-based therapies are currently under investigation. For example, hematopoietic stem cells (HSCs) were shown to give rise to vascular cells involved in neoangiogenesis; so, they have been tested in variety of animal models and small-scale clinical trials. Improvement in blood flow and tissue functionality was observed and adverse effects were not apparent. However, success of stem cell therapy is limited by the number of functional stem cells for clinical application. Numerous attempts are underway to address this issue via strategies that involve ex vivo expansion of stem cells preserving their stemness. This chapter outlines the mechanism of therapeutic angiogenesis, sources of HSCs, various methods of ex vivo expansion of HSCs via genetic regulators, cytokines and biomaterial scaffolds, and their preclinical and clinical applications.

Original languageEnglish (US)
Title of host publicationStem Cells and Cancer Stem Cells, Volume 2
Subtitle of host publicationStem Cells and Cancer Stem Cells, Therapeutic Applications in Disease and Injury: Volume 2
PublisherSpringer Netherlands
Pages219-229
Number of pages11
ISBN (Electronic)9789400720169
ISBN (Print)9789400720152
DOIs
StatePublished - Jan 1 2012

Keywords

  • Angiogenic
  • Hematopoietic stem cells
  • Ischemia
  • Stromal cells
  • Thrombopoietin
  • Vasculogenesis

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Lu, J., Aggarwal, R., Pompili, V. J., & Das, H. (2012). Ex vivo expanded hematopoietic stem cells for ischemia. In Stem Cells and Cancer Stem Cells, Volume 2: Stem Cells and Cancer Stem Cells, Therapeutic Applications in Disease and Injury: Volume 2 (pp. 219-229). Springer Netherlands. https://doi.org/10.1007/978-94-007-2016-9_23