Exercise training and sympathetic regulation in experimental heart failure

Irving H. Zucker, Kaushik P. Patel, Harold D. Schultz, Yi Fan Li, Wei Wang, Rainer U. Pliquett

Research output: Contribution to journalReview articlepeer-review

56 Scopus citations


In this review, we put forth the hypothesis that reduction in sympathetic outflow after exercise training of animals with heart failure is mediated by reductions in angiotensin II and in angiotensin type 1 receptors. Furthermore, we provide evidence that exercise training provides for an upregulation of the neuronal isoform of nitric oxide synthase in the central nervous system that is sympathoinhibitory.

Original languageEnglish (US)
Pages (from-to)107-111
Number of pages5
JournalExercise and Sport Sciences Reviews
Issue number3
StatePublished - Jul 2004


  • Angiotensin II
  • Myocardial infarction
  • Nitric oxide synthase
  • Pacing

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation


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