Exercise training normalizes enhanced sympathetic activation from the paraventricular nucleus in chronic heart failure: Role of angiotensin II

Hong Zheng, Neeru M. Sharma, Xuefei Liu, Kaushik P. Patel

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Exercise training (ExT) normalizes the increased sympathetic outflow in heart failure (HF), but the underlying mechanisms are not known. We hypothesized ExT would normalize the augmented activation of the paraventricular nucleus (PVN) via an angiotensinergic mechanism during HF. Four groups of rats used were the following: 1) sham-sedentary (Sed); 2) sham-ExT; 3) HF-Sed, and 4) HF-ExT. HF was induced by left coronary artery ligation. Four weeks after surgery, 3 wk of treadmill running was performed in ExT groups. The number of FosB-positive cells in the PVN was significantly increased in HF-Sed group compared with the sham-Sed group. ExT normalized (negated) this increase in the rats with HF. In anesthetized condition, the increases in renal sympathetic nerve activity (RSNA), mean arterial pressure (MAP), and heart rate (HR) in response to microinjection of angiotensin (ANG) II (50~200 pmol) in the PVN of HF-Sed group were significantly greater than of the sham-Sed group. In the HF-ExT group the responses to microinjection of ANG II were not different from sham-Sed or sham-ExT groups. Blockade of ANG II type 1 (AT 1) receptors with losartan in the PVN produced a significantly greater decrease in RSNA, MAP, and HR in HF-Sed group compared with sham-Sed group. ExT prevented the difference between HF and sham groups. AT 1 receptor protein expression was increased 50% in HF-Sed group compared with sham-Sed group. In the HF-ExT group, AT 1 receptor protein expression was not significantly different from sham-Sed or sham-ExT groups. In conclusion, one mechanism by which ExT alleviates elevated sympathetic outflow in HF may be through normalization of angiotensinergic mechanisms within the PVN.

Original languageEnglish (US)
Pages (from-to)R387-R394
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume303
Issue number4
DOIs
StatePublished - Aug 15 2012

Keywords

  • At1 receptors
  • Blood pressure
  • Central nervous system
  • Renal nerve activity

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Fingerprint Dive into the research topics of 'Exercise training normalizes enhanced sympathetic activation from the paraventricular nucleus in chronic heart failure: Role of angiotensin II'. Together they form a unique fingerprint.

  • Cite this