TY - JOUR
T1 - Exocrine pancreatic secretion in the syrian golden hamster Mesocricetus auratus-III. Effects of carcinogen administration and development of pancreas cancer
AU - Helgeson, A. Scott
AU - Lawson, Terence
AU - Pour, Parviz
N1 - Funding Information:
Acknowledgements--This study was supported by a grant from the National Cancer Institute National Pancreatic Cancer Project No. 1 R26 CA20198.
PY - 1984
Y1 - 1984
N2 - 1. 1. The short- and long-term effects of the administration of the pancreas carcinogen N-nitrosobis(2-oxopropyl)amine (BOP) on pancreatic exocrine secretion were examined in Syrian hamsters with and without stimulation by secretin and pancreozymin. 2. 2. Protein concentration, flow rate, pH and ion content, (Na+, K+, Ca2+, Mg2+, HCO-3, Cl-, HPO42- and SO42-) were measured. 3. 3. An immediate effect of BOP is the stimulation of flow rate in females and of protein secretion in both sexes. 4. 4. Multiple doses of BOP significantly altered the parameters mentioned in Section 2 only in the later stages of tumorigenesis. When these animals were stimulated with secretin or pancreozymin large decreases in flow rate and protein content of secretions were observed as early as 8 weeks after BOP treatment. 5. 5. Insulin-like immunoreactivity and growth hormone-like immunoreactivity were detected in collected pancreatic secretions.
AB - 1. 1. The short- and long-term effects of the administration of the pancreas carcinogen N-nitrosobis(2-oxopropyl)amine (BOP) on pancreatic exocrine secretion were examined in Syrian hamsters with and without stimulation by secretin and pancreozymin. 2. 2. Protein concentration, flow rate, pH and ion content, (Na+, K+, Ca2+, Mg2+, HCO-3, Cl-, HPO42- and SO42-) were measured. 3. 3. An immediate effect of BOP is the stimulation of flow rate in females and of protein secretion in both sexes. 4. 4. Multiple doses of BOP significantly altered the parameters mentioned in Section 2 only in the later stages of tumorigenesis. When these animals were stimulated with secretin or pancreozymin large decreases in flow rate and protein content of secretions were observed as early as 8 weeks after BOP treatment. 5. 5. Insulin-like immunoreactivity and growth hormone-like immunoreactivity were detected in collected pancreatic secretions.
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U2 - 10.1016/0742-8413(84)90150-6
DO - 10.1016/0742-8413(84)90150-6
M3 - Article
C2 - 6141875
AN - SCOPUS:0021344046
SN - 1367-8280
VL - 77
SP - 191
EP - 197
JO - Comparative Biochemistry and Physiology - C Pharmacology Toxicology and Endocrinology
JF - Comparative Biochemistry and Physiology - C Pharmacology Toxicology and Endocrinology
IS - 1
ER -