Expanding Therapeutic Options for Older Adults: Case-Based Updates in Breast and Lung Cancer

Allison Magnuson, Rawad Elias, Thuy Koll

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Oncology care has become increasingly complex, with a dramatic increase in the number of available therapy options. Many newly developed medications have novel mechanisms of action and include targeted therapies and immunotherapy options. These agents typically have unique side effects that differ from more traditional cytotoxic chemotherapy regimens. Older adults represent the majority of patients with cancer and it is important for geriatricians and primary care providers for older adults to have a general understanding of newer agents and novel therapies, in order to aid in decision-making and supportive care strategies during oncology treatment. This review provides a case-based approach to discussing emerging therapeutic treatment options, including targeted therapies and immune-based therapies, in two common malignancies affecting older adults. Incorporation of available evidence of specific novel therapies in older adult populations is discussed. J Am Geriatr Soc 67:1012–1019, 2019.

Original languageEnglish (US)
Pages (from-to)1012-1019
Number of pages8
JournalJournal of the American Geriatrics Society
Issue number5
StatePublished - May 2019


  • cancer therapy
  • case-based review
  • geriatric oncology

ASJC Scopus subject areas

  • Geriatrics and Gerontology


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