@article{9f58669217f64c23ab1c87180d171862,
title = "Experimental evidence for adaptation to species-specific gut microbiota in house mice",
abstract = "The gut microbial communities of mammals have codiversified with host species, and changes in the gut microbiota can have profound effects on host fitness. Therefore, the gut microbiota may drive adaptation in mammalian species, but this possibility is underexplored. Here, we show that the gut microbiota has codiversified with mice in the genus Mus over the past ~6 million years, and we present experimental evidence that the gut microbiota has driven adaptive evolution of the house mouse, Mus musculus domesticus. Phylogenetic analyses of metagenomeassembled bacterial genomic sequences revealed that gut bacterial lineages have been retained within and diversified alongside Mus species over evolutionary time. Transplantation of gut microbiotas from various Mus species into germfree M. m. domesticus showed that foreign gut microbiotas slowed growth rate and upregulated macrophage inflammatory protein in hosts. These results suggest adaptation by M. m. domesticus to its gut microbiota since it diverged from other Mus species.",
keywords = "Evolutionary biology, Metagenomics, Microbial ecology",
author = "Moeller, {Andrew H.} and Gomes-Neto, {Jo{\~a}o C.} and Sara Mantz and Hatem Kittana and Munoz, {Rafael R.Segura} and Schmaltz, {Robert J.} and Ramer-Tait, {Amanda E.} and Nachman, {Michael W.}",
note = "Funding Information: We thank Devin Rose and Nabaraj Banjara and Renee Schmaltz (University of Nebraska—Lincoln [UNL]) for technical assistance as well as the staff at the UNL Gnotobiotic Mouse Facility for animal husbandry services. This work was supported by NIH grants to M.W.N. (RO1 GM074245 and R01 GM127468) and a Miller Postdoctoral Fellowship to A.H.M. A.H.M. designed the study, analyzed data, and wrote the paper. J.C.G.-N., S.M., H.K., R.R.S.M., and R.J.S. conducted experiments. A.E.R.-T. and M.W.N. designed the study, edited the manuscript, and provided reagents. We declare that we have no competing interests. Funding Information: We thank Devin Rose and Nabaraj Banjara and Renee Schmaltz (University of Nebraska-Lincoln [UNL]) for technical assistance as well as the staff at the UNL Gnotobiotic Mouse Facility for animal husbandry services. This work was supported by NIH grants to M.W.N. (RO1 GM074245 and R01 GM127468) and a Miller Postdoctoral Fellowship to A.H.M. A.H.M. designed the study, analyzed data, and wrote the paper. J.C.G.-N., S.M., H.K., R.R.S.M., and R.J.S. conducted experiments. A.E.R.-T. and M.W.N. designed the study, edited the manuscript, and provided reagents. We declare that we have no competing interests. Publisher Copyright: {\textcopyright} 2019 Moeller et al.",
year = "2019",
doi = "10.1128/mSphere.00387-19",
language = "English (US)",
volume = "4",
journal = "mSphere",
issn = "2379-5042",
publisher = "American Society for Microbiology",
number = "4",
}