TY - JOUR
T1 - Experimental Retinal Detachment
T2 - Vii. Intravenous Horseradish Peroxidase Diffusion Across the Blood-Retinal Barrier
AU - Toris, Carol B.
AU - Pederson, Jonathan E.
PY - 1984/5
Y1 - 1984/5
N2 - Intravenous horseradish peroxidase (HRP) was administered to cynomolgus monkeys to study chorioretinal diffusion in eyes with retinal detachment. In control eyes, HRP was contained within the choriocapillaris and did not penetrate beyond Bruch's membrane. In addition, HRP was confined within blood vessels of the sensory retina. In detached eyes, HRP diffused out of the choriocapillaris and through the intercellular spaces of the retinal pigment epithelium (RPE), where it was blocked by zonulae occludentes. Occasionally HRP was found within pinocytotic vesicles of the RPE. It was also confined within retinal blood vessels by their endothelial cells. It is concluded that the blood-retinal barrier remains intact to HRP following long-term rhegmatogenous retinal detachment. However, a slight alteration exists at the choriocapillaris in detached eyes.
AB - Intravenous horseradish peroxidase (HRP) was administered to cynomolgus monkeys to study chorioretinal diffusion in eyes with retinal detachment. In control eyes, HRP was contained within the choriocapillaris and did not penetrate beyond Bruch's membrane. In addition, HRP was confined within blood vessels of the sensory retina. In detached eyes, HRP diffused out of the choriocapillaris and through the intercellular spaces of the retinal pigment epithelium (RPE), where it was blocked by zonulae occludentes. Occasionally HRP was found within pinocytotic vesicles of the RPE. It was also confined within retinal blood vessels by their endothelial cells. It is concluded that the blood-retinal barrier remains intact to HRP following long-term rhegmatogenous retinal detachment. However, a slight alteration exists at the choriocapillaris in detached eyes.
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U2 - 10.1001/archopht.1984.01040030600030
DO - 10.1001/archopht.1984.01040030600030
M3 - Article
C2 - 6721769
AN - SCOPUS:0021336502
SN - 0003-9950
VL - 102
SP - 752
EP - 756
JO - Archives of Ophthalmology
JF - Archives of Ophthalmology
IS - 5
ER -