Exploiting enzymatic dynamic reductive kinetic resolution (DYRKR) in stereocontrolled synthesis

Gregory A. Applegate, David B. Berkowitz

Research output: Contribution to journalReview articlepeer-review

54 Scopus citations

Abstract

Over the past two decades, the domains of both frontline synthetic organic chemistry and process chemistry have seen an increase in crosstalk between asymmetric organic/organometallic approaches and enzymatic approaches to stereocontrolled synthesis. This review highlights the particularly auspicious role for dehydrogenase enzymes in this endeavor, with a focus on dynamic reductive kinetic resolutions (DYRKR) to "deracemize" building blocks, often setting two stereocenters in so doing. The scope and limitations of such dehydrogenase-mediated processes are overviewed, as are future possibilities for the evolution of enzymatic DYRKR.

Original languageEnglish (US)
Pages (from-to)1619-1632
Number of pages14
JournalAdvanced Synthesis and Catalysis
Volume357
Issue number8
DOIs
StatePublished - May 1 2015

Keywords

  • asymmetric synthesis
  • biocatalysis
  • dehydrogenase enzymes
  • deracemization
  • dynamic kinetic resolution

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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