Exploiting enzymatic dynamic reductive kinetic resolution (DYRKR) in stereocontrolled synthesis

Gregory A. Applegate, David B. Berkowitz

Research output: Contribution to journalReview article

43 Scopus citations

Abstract

Over the past two decades, the domains of both frontline synthetic organic chemistry and process chemistry have seen an increase in crosstalk between asymmetric organic/organometallic approaches and enzymatic approaches to stereocontrolled synthesis. This review highlights the particularly auspicious role for dehydrogenase enzymes in this endeavor, with a focus on dynamic reductive kinetic resolutions (DYRKR) to "deracemize" building blocks, often setting two stereocenters in so doing. The scope and limitations of such dehydrogenase-mediated processes are overviewed, as are future possibilities for the evolution of enzymatic DYRKR.

Original languageEnglish (US)
Pages (from-to)1619-1632
Number of pages14
JournalAdvanced Synthesis and Catalysis
Volume357
Issue number8
DOIs
StatePublished - May 1 2015

Keywords

  • asymmetric synthesis
  • biocatalysis
  • dehydrogenase enzymes
  • deracemization
  • dynamic kinetic resolution

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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