Exploiting self-assembly for ligand-scaffold optimization: Substrate-tailored ligands for efficient catalytic asymmetric hydroboration

Shin A. Moteki; James M. Takacs

doi:10.1002/anie.200703127

Exploiting self-assembly for ligand-scaffold optimization: Substrate-tailored ligands for efficient catalytic asymmetric hydroboration

Shin A. Moteki, James M. Takacs

Chemistry

Research output: Contribution to journal › Article › peer-review

73 Scopus citations

Abstract

(Chemical Equation Presented) Mix and match: A self-assembled ligand library (SAL XY) affords a wide range of R/S ratios in Rh-catalyzed asymmetric hydroboration (see scheme; nbd = 2,5-norbornadiene, R* is a chiral substituent). Ligand-scaffold optimization reveals "substrate- tailored" ligands that afford high regio- and enantioselectivity for a variety of ortho-substituted styrene derivatives.

Original language	English (US)
Pages (from-to)	894-897
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	47
Issue number	5
DOIs	https://doi.org/10.1002/anie.200703127
State	Published - 2008

Keywords

Asymmetric synthesis
Combinatorial chemistry
Hydroboration
Self-assembly
Stereoselective catalysis

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.200703127

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AU - Takacs, James M.

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AB - (Chemical Equation Presented) Mix and match: A self-assembled ligand library (SAL XY) affords a wide range of R/S ratios in Rh-catalyzed asymmetric hydroboration (see scheme; nbd = 2,5-norbornadiene, R* is a chiral substituent). Ligand-scaffold optimization reveals "substrate- tailored" ligands that afford high regio- and enantioselectivity for a variety of ortho-substituted styrene derivatives.

KW - Asymmetric synthesis

KW - Combinatorial chemistry

KW - Hydroboration

KW - Self-assembly

KW - Stereoselective catalysis

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Exploiting self-assembly for ligand-scaffold optimization: Substrate-tailored ligands for efficient catalytic asymmetric hydroboration

Abstract

Keywords

ASJC Scopus subject areas

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