Exploration of relative chemoselectivity in the hydrodechlorination of 2-chloropyridines

Nihar Kinarivala, Paul C. Trippier

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


The chemoselectivity of hydrodechlorination in 2-chloropyridine derivatives possessing reduction-sensitive functionalities is examined. The reaction conditions employed tolerate a variety of functionalities illustrating highly chemoselective hydrodechlorination in the presence of nitrile, allyl, terminal olefin, and nitroamine functionalities in excellent yield. Chemoselective deprotection of carboxybenzyl ethers is illustrated in moderate yield.

Original languageEnglish (US)
Pages (from-to)5386-5389
Number of pages4
JournalTetrahedron Letters
Issue number39
StatePublished - Sep 24 2014
Externally publishedYes


  • Chemoselectivity
  • Hydrogenation
  • Pyridines
  • Reduction

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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