Expression of nicotinic acetylcholine receptor mRNA in the adult rat peripheral vestibular system

Hakim Hiel; Ana B. Elgoyhen; Dennis G. Drescher; Barbara J. Morley

doi:10.1016/S0006-8993(96)01046-3

Expression of nicotinic acetylcholine receptor mRNA in the adult rat peripheral vestibular system

Hakim Hiel, Ana B. Elgoyhen, Dennis G. Drescher, Barbara J. Morley

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76 Scopus citations

Abstract

The mRNA expression of the neuronal nicotinic acetylcholine receptor subunits was determined in adult rat vestibular end-organs and in Scarpa's ganglion (SCG) by in situ hybridization with [³⁵S]riboprobes. Neurons in the SCG expressed the α4-7 and β2-3 mRNAs, but not α3 or β4 mRNAs. Not all SCG neurons expressed every mRNA found in SCG. The α6 and β2-3 riboprobes labeled all neurons, but α4, α5, and α7 mRNAs were selectively expressed in one or more subpopulations of SCG neurons. Vestibular sensory hair cells, in contrast, expressed only α9 mRNA.

Original language	English (US)
Pages (from-to)	347-352
Number of pages	6
Journal	Brain Research
Volume	738
Issue number	2
DOIs	https://doi.org/10.1016/S0006-8993(96)01046-3
State	Published - Nov 4 1996

Keywords

Scarpa's ganglion
efferent
hair cell
hybridization, in situ
nicotinic acetylcholine receptor
vestibular

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/S0006-8993(96)01046-3

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title = "Expression of nicotinic acetylcholine receptor mRNA in the adult rat peripheral vestibular system",

abstract = "The mRNA expression of the neuronal nicotinic acetylcholine receptor subunits was determined in adult rat vestibular end-organs and in Scarpa's ganglion (SCG) by in situ hybridization with [35S]riboprobes. Neurons in the SCG expressed the α4-7 and β2-3 mRNAs, but not α3 or β4 mRNAs. Not all SCG neurons expressed every mRNA found in SCG. The α6 and β2-3 riboprobes labeled all neurons, but α4, α5, and α7 mRNAs were selectively expressed in one or more subpopulations of SCG neurons. Vestibular sensory hair cells, in contrast, expressed only α9 mRNA.",

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AU - Hiel, Hakim

AU - Elgoyhen, Ana B.

AU - Drescher, Dennis G.

AU - Morley, Barbara J.

PY - 1996/11/4

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N2 - The mRNA expression of the neuronal nicotinic acetylcholine receptor subunits was determined in adult rat vestibular end-organs and in Scarpa's ganglion (SCG) by in situ hybridization with [35S]riboprobes. Neurons in the SCG expressed the α4-7 and β2-3 mRNAs, but not α3 or β4 mRNAs. Not all SCG neurons expressed every mRNA found in SCG. The α6 and β2-3 riboprobes labeled all neurons, but α4, α5, and α7 mRNAs were selectively expressed in one or more subpopulations of SCG neurons. Vestibular sensory hair cells, in contrast, expressed only α9 mRNA.

AB - The mRNA expression of the neuronal nicotinic acetylcholine receptor subunits was determined in adult rat vestibular end-organs and in Scarpa's ganglion (SCG) by in situ hybridization with [35S]riboprobes. Neurons in the SCG expressed the α4-7 and β2-3 mRNAs, but not α3 or β4 mRNAs. Not all SCG neurons expressed every mRNA found in SCG. The α6 and β2-3 riboprobes labeled all neurons, but α4, α5, and α7 mRNAs were selectively expressed in one or more subpopulations of SCG neurons. Vestibular sensory hair cells, in contrast, expressed only α9 mRNA.

KW - Scarpa's ganglion

KW - efferent

KW - hair cell

KW - hybridization, in situ

KW - nicotinic acetylcholine receptor

KW - vestibular

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Expression of nicotinic acetylcholine receptor mRNA in the adult rat peripheral vestibular system

Abstract

Keywords

ASJC Scopus subject areas

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