Expression of PKC-beta or cyclin D2 predicts for inferior survival in diffuse large B-cell lymphoma

Christine P. Hans, Dennis D. Weisenburger, Timothy C. Greiner, Wing C. Chan, Patricia Aoun, Gregory T. Cochran, Zenggang Pan, Lynette M. Smith, James C. Lynch, Robert Gregory Bociek, Philip J. Bierman, Julie M. Vose, James O. Armitage

Research output: Contribution to journalArticle

97 Scopus citations

Abstract

We sought to determine whether identification of poor-risk subgroups of diffuse large B-cell lymphoma (DLBCL) using immunohistochemical stains would have practical utility with regard to prognosis and therapeutic decisions. Tissue microarray blocks were created using replicate samples of formalin-fixed, paraffin-embedded tissue from 200 cases of de novo DLBCL. The sections were stained with antibodies to proteins that are expressed by activated or proliferating B cells including MUM1, FOXP1, bcl-2, survivin, protein kinase C-beta (PKC-β), cyclin D2, cyclin D3, and Ki-67. In univariate analysis, tumor expression of cyclin D2 (P=0.025) or PKC-β (P=0.015) was associated with a worse overall survival, whereas none of the other markers was predictive of overall survival. Patients with DLBCL that expressed either cyclin D2 or PKC-β had a 5-year overall survival of only 30% as compared to 52% for those who were negative for both markers (P=0.0019). In multivariate analysis, the expression of cyclin D2 or PKC-β was an independent predictor of poor overall survival (P=0.035). Cyclin D2 and PKC-β expression will be useful in designing a 'biological prognostic index' for patients with DLBCL.

Original languageEnglish (US)
Pages (from-to)1377-1384
Number of pages8
JournalModern Pathology
Volume18
Issue number10
DOIs
StatePublished - Oct 2005

Keywords

  • Cyclin D2
  • Diffuse large B-cell lymphoma
  • Immunohistochemistry
  • Protein kinase C-beta

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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