Retinoblastomas arise by the loss of the retinoblastoma (RB) gene. The isolation of the RB gene and its expression in RB protein defective tumor cells permits direct tests of the ability of the protein to act as a tumor suppressor. We demonstrate that a functional RB gene introduced into WERI-Rb-27 retinoblastoma cells by retrovirally mediated gene transfer can suppress their tumorigenicity in immunodefective mice.
|Original language||English (US)|
|Number of pages||4|
|Journal||Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research|
|State||Published - May 1990|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology