Extracellular matrix and fibroblast communication following myocardial infarction

Yonggang Ma, Ganesh V. Halade, Merry L. Lindsey

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

The extracellular matrix (ECM) provides structural support by serving as a scaffold for cells, and as such the ECM maintains normal tissue homeostasis and mediates the repair response following injury. In response to myocardial infarction (MI), ECM expression is generally upregulated in the left ventricle (LV), which regulates LV remodeling by modulating scar formation. The ECM directly affects scar formation by regulating growth factor release and cell adhesion and indirectly affects scar formation by regulating the inflammatory, angiogenic, and fibroblast responses. This review summarizes the current literature on ECM expression patterns and fibroblast mechanisms in the myocardium, focusing on the ECM response to MI. In addition, we discuss future research areas that are needed to better understand the molecular mechanisms of ECM action, both in general and as a means to optimize infarct healing.

Original languageEnglish (US)
Pages (from-to)848-857
Number of pages10
JournalJournal of Cardiovascular Translational Research
Volume5
Issue number6
DOIs
StatePublished - Dec 2012

Keywords

  • Cardiac myocytes
  • Cell-ECM communication
  • Extracellular matrix
  • Fibroblasts
  • Myocardial infarction
  • Proteomics

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Pharmaceutical Science
  • Cardiology and Cardiovascular Medicine
  • Genetics(clinical)

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