Extracellular matrix biomarkers of adverse remodeling after myocardial infarction

Kristine Y. DeLeon, Lisandra E.de Castro Brás, Yonggang Ma, Ganesh V. Halade, Jianhua Zhang, Merry L. Lindsey

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Approximately every minute, someone will die from a myocardial infarction (MI). A MI is the result of an obstruction of blood supply causing the heart to undergo complex structural and functional changes in the left ventricular wall, known as ventricular remodeling. Cardiomyocytes undergo necrosis rapidly after the onset of injury, leading to early accumulation of neutrophils, activation of metalloproteinases, and degradation of the stromal tissue, eventually leading to formation of a collagen scar. Circulating factors related to inflammatory and fibrotic responses are key predictors of extracellular matrix (ECM) changes that occur after MI. Changes in the collagen network of the ECM can alter myocardial stiffness, consequently leading to cardiac hypertrophy, fibrosis, and LV dysfunction. Proteins and peptides of the ECM are promising biomarkers for MI. This book chapter provides an overview of key ECM biomarkers involved in adverse remodeling post-MI and their practical applications.

Original languageEnglish (US)
Title of host publicationCardiac Remodeling
Subtitle of host publicationMolecular Mechanisms
PublisherSpringer New York
Pages383-412
Number of pages30
ISBN (Electronic)9781461459309
ISBN (Print)9781461459293
DOIs
StatePublished - Jan 1 2013

Keywords

  • Biomarkers
  • Cardiac remodeling
  • Extracellular matrix
  • Myocardial infarction

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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