Extracellular superoxide dismutase and risk of COPD

Rebecca E. Oberley-Deegan, Elizabeth A. Regan, Vuokko L. Kinnula, James D. Crapo

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Chronic obstructive pulmonary disease (COPD) is a major public health problem worldwide. COPD is strongly related to cigarette smoke exposure, but not all smokers develop the disease. It is thought that COPD progresses slowly over time stimulated by environmental exposures, including free radicals from cigarette smoke, which ultimately establish chronic inflammation and result in a progressive destruction of lung tissues. COPD is known to occur in family clusters, which has prompted interest in determining genetic risk factors for the disease. Several genetic studies have identified an association between extracellular superoxide dismutase (ECSOD) polymorphisms and risk for developing COPD. ECSOD is an antioxidant protein that scavenges superoxide free radicals from cigarette smoke and protects the lungs from free radical damage and chronic inflammation.

Original languageEnglish (US)
Pages (from-to)307-312
Number of pages6
JournalCOPD: Journal of Chronic Obstructive Pulmonary Disease
Volume6
Issue number4
DOIs
StatePublished - Nov 4 2009

Keywords

  • COPD
  • ECSOD
  • Free radicals
  • Genetic Association

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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