Extracellular Vesicle MicroRNAs in Heart Failure: Pathophysiological Mediators and Therapeutic Targets

Changhai Tian, Jessica N. Ziegler, Irving H. Zucker

Research output: Contribution to journalReview articlepeer-review

Abstract

Extracellular vesicles (EVs) are emerging mediators of intracellular and inter-organ communications in cardiovascular diseases (CVDs), especially in the pathogenesis of heart failure through the transference of EV-containing bioactive substances. microRNAs (miRNAs) are contained in EV cargo and are involved in the progression of heart failure. Over the past several years, a growing body of evidence has suggested that the biogenesis of miRNAs and EVs is tightly regulated, and the sorting of miRNAs into EVs is highly selective and tightly controlled. Extracellular miRNAs, particularly circulating EV-miRNAs, have shown promising potential as prognostic and diagnostic biomarkers for heart failure and as therapeutic targets. In this review, we summarize the latest progress concerning the role of EV-miRNAs in HF and their application in a therapeutic strategy development for heart failure.

Original languageEnglish (US)
Article number2145
JournalCells
Volume12
Issue number17
DOIs
StatePublished - Sep 2023

Keywords

  • biomarkers
  • extracellular vesicles
  • heart failure
  • microRNAs
  • sorting mechanism

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology

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