Extranodal marginal zone lymphoma of the dura mater with IgH/MALT1 translocation and review of literature

Sharathkumar Bhagavathi, Timothy C. Greiner, Syed A. Kazmi, Kai Fu, Warren G. Sanger, Wing C. Chan

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Primary central nervous system lymphoma (PCNSL) is an extranodal non-Hodgkin lymphoma involving brain, intraocular structures and spinal cord, without evidence of systemic disease. The majority of PCNSLs are diffuse large B-cell type. We encountered a rare case of primary dural marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT) with extension into the brain in a 59-year-old man. A magnetic resonance imaging scan showed a 22-mm tumor located in the left posterior temporal lobe extending from the dura. Histopathology revealed a lymphoplasmacytic infiltration of the dura and the brain parenchyma in a perivascular pattern. Immunohistochemical and in situ hybridization studies showed a B-cell phenotype with kappa light chain restriction. Fluorescent in situ hybridization study showed a t(14;18)(q32; q21) with immunoglobulin heavy-chain/MALT1 fusion. The molecular study for immunoglobulin heavy-chain gene rearrangement by polymerase chain reaction showed a clonal gene rearrangement.

Original languageEnglish (US)
Pages (from-to)131-137
Number of pages7
JournalJournal of Hematopathology
Issue number2
StatePublished - 2008


  • Dura
  • FISH
  • Primary CNS.MALT lymphoma
  • T(1418).MALT1 translocation

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Hematology

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