Extravasation of polymeric nanomedicines across tumor vasculature

Michael K. Danquah, Xin A. Zhang, Ram I. Mahato

Research output: Contribution to journalReview article

126 Scopus citations

Abstract

Tumor microvasculature is fraught with numerous physiological barriers which hinder the efficacy of anticancer agents. These barriers include chaotic blood supply, poor tumor vasculature permeability, limited transport across the interstitium due to high interstitial pressure and absence of lymphatic network. Abnormal microvasculature also leads to hypoxia and acidosis which limits effectiveness of chemotherapy. These barriers restrict drug or drug carrier extravasation which hampers tumor regression. Targeting key features of the tumor microenvironment such as tumor microvessels, interstitial hypertension and tumor pH is a promising approach to improving the efficacy of anticancer drugs. This review highlights the current knowledge on the distinct tumor microenvironment generated barriers which limit extravasation of drugs and focuses on modalities for overcoming these barriers using multi-functional polymeric carriers. Special attention is given to utilizing polymeric nanomedicines to facilitate extravasation of anticancer drugs for future cancer therapy.

Original languageEnglish (US)
Pages (from-to)623-639
Number of pages17
JournalAdvanced Drug Delivery Reviews
Volume63
Issue number8
DOIs
StatePublished - Jul 18 2011

Keywords

  • Drug delivery
  • Extravasation
  • Nanomedicines
  • Tumor targeting
  • Tumor vasculature

ASJC Scopus subject areas

  • Pharmaceutical Science

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