F-18-fluoro-deoxy-glucose positron emission tomography in the assessment of peripheral T-cell lymphomas

S. Bishu, J. M. Quigley, J. Schmitz, S. R. Bishu, R. A. Stemm, S. M. Olsasky, S. Paknikar, K. H. Holdeman, J. O. Armitage, J. H. Hankins

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36 Scopus citations

Abstract

F-18-fluoro-deoxy-glucose positron emission tomography (PET) is highly sensitive and specific in the imaging of B-cell lymphomas. In contrast, its utility in the diagnostic evaluation of T-cell lymphomas is less defined. In this article, we present our finding utilizing PET in peripheral T-cell lymphomas (PTCL). A retrospective review of patients who underwent PET examinations at our institution produced 24 PET examinations among patients with PTCL. A lesion-based analysis was undertaken to evaluate the diagnostic accuracy of PET in PTCL. PET findings were compared with a standard of reference and sensitivity, specificity, positive and negative predictive values were calculated. PET had an overall sensitivity of 86% and specificity of 100%. PET had high sensitivity (95%) at nodal and non-cutaneous extra-nodal sites and poor sensitivity (13%) at cutaneous sites. The mean SUV of abnormal foci in anaplastic large cell lymphoma was 11mg/ml (range: 3-40), and PTCL-unclassified was 8mg/ml (range: 1-23).

Original languageEnglish (US)
Pages (from-to)1531-1538
Number of pages8
JournalLeukemia and Lymphoma
Volume48
Issue number8
DOIs
StatePublished - Aug 2007

Keywords

  • Diagnostic accuracy
  • PET
  • PTCL

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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    Bishu, S., Quigley, J. M., Schmitz, J., Bishu, S. R., Stemm, R. A., Olsasky, S. M., Paknikar, S., Holdeman, K. H., Armitage, J. O., & Hankins, J. H. (2007). F-18-fluoro-deoxy-glucose positron emission tomography in the assessment of peripheral T-cell lymphomas. Leukemia and Lymphoma, 48(8), 1531-1538. https://doi.org/10.1080/10428190701344915