Fabrication of aligned PCL scaffold and its guidance for cell growth

Hong Li, Zhenzhao Guo, Xiaowei Li, Xiaoyan Liu, Xuejun Wen, Bo Xue

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Aligned and random poly(ε-caprolactone)(PCL) fibrous scaffolds were fabricated via the eletrospinning technique. The morphology, crystallization and mechanical properties of the electrospun scaffolds were characterized by scanning electron microscopy (SEM), wide angle X-ray diffraction(WAXD) and an universal machine test. Osteoblasts were seeded on electrospun scaffolds and the cell growth was evaluated by laser scanning confocal microscope (LSCM) and SEM. The results indicate that the electrospun fibers are smooth and uniform, and about 86.14% fibers are aligned along the selected direction. The tensile strength of the aligned fibers is (27.63±0.75) MPa, which is 232% stronger than that of the random fibers. The elastic modulus does not change significantly, and the elongation at break decreases significantly. The aligned fibers could provide a better guidance towards the cell growth.

Original languageEnglish (US)
Pages (from-to)166-169
Number of pages4
JournalGaofenzi Cailiao Kexue Yu Gongcheng/Polymeric Materials Science and Engineering
Volume28
Issue number10
StatePublished - Oct 2012
Externally publishedYes

Keywords

  • Aligned fibrous scaffold
  • Cell
  • Electrospining
  • Poly(ε-caprolactone)

ASJC Scopus subject areas

  • Process Chemistry and Technology
  • Polymers and Plastics

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