Fabrication of injectable and superelastic nanofiber rectangle matrices (“peanuts”) and their potential applications in hemostasis

Shixuan Chen, Mark A. Carlson, Yu Shrike Zhang, Yong Hu, Jingwei Xie

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Uncontrolled hemorrhage, which typically involves the torso and/or limb junctional zones, remains a great challenge in the prehospital setting. Here, we for the first time report an injectable and superelastic nanofiber rectangle matrix (“peanut”) fabricated by a combination of electrospinning, gas foaming, hydrogel coating and crosslinking techniques. The compressed nanofiber peanut is capable of re-expanding to its original shape in atmosphere, water and blood within 10 s. Such nanofiber peanuts exhibit greater capacity of water/blood absorption compared to current commercial products and high efficacy in whole blood clotting assay, in particular for thrombin-immobilized samples. These nanofiber peanuts are capable of being packed into a syringe for injection. Further in vivo tests indicated the effectiveness of nanofiber peanuts for hemostasis in a porcine liver injury model. This new class of nanofiber-based materials may hold great promise for hemostatic applications.

Original languageEnglish (US)
Pages (from-to)46-59
Number of pages14
JournalBiomaterials
Volume179
DOIs
StatePublished - Oct 2018

Keywords

  • Electrospinning
  • Hemostasis
  • Injectable
  • Nanofiber rectangle matrix
  • Superelastic

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

Fingerprint Dive into the research topics of 'Fabrication of injectable and superelastic nanofiber rectangle matrices (“peanuts”) and their potential applications in hemostasis'. Together they form a unique fingerprint.

  • Cite this