Fabrication of Nanofiber Scaffolds With Gradations in Fiber Organization and Their Potential Applications

Jingwei Xie; Bing Ma; Praveesuda Lorwattanapongsa Michael; Franklin D. Shuler

doi:10.1002/mabi.201200115

Fabrication of Nanofiber Scaffolds With Gradations in Fiber Organization and Their Potential Applications

Jingwei Xie, Bing Ma, Praveesuda Lorwattanapongsa Michael, Franklin D. Shuler

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

A new and simple method for fabrication of nanofiber scaffolds with gradations in fiber organization is reported. The nanofiber organization, achieved by deposition of random fibers on the uniaxially aligned nanofiber mat in a gradient manner, directed morphological changes of applied adipose-derived stem cells. These morphological changes and resultant biochemical changes can help mimic the structural orientation of complex biomechanical structures like the collagen fiber structure at the tendon-to-bone insertion site. In addition, chemical gradients can be established through nanoencapsulation in this novel scaffold allowing for enhanced biomedical applications.

Original language	English (US)
Pages (from-to)	1336-1341
Number of pages	6
Journal	Macromolecular Bioscience
Volume	12
Issue number	10
DOIs	https://doi.org/10.1002/mabi.201200115
State	Published - Oct 2012
Externally published	Yes

Keywords

Electrospinning
Gradient
Nanofibers
Organization
Tendon-to-bone

ASJC Scopus subject areas

Biotechnology
Bioengineering
Biomaterials
Polymers and Plastics
Materials Chemistry

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AU - Shuler, Franklin D.

PY - 2012/10

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AB - A new and simple method for fabrication of nanofiber scaffolds with gradations in fiber organization is reported. The nanofiber organization, achieved by deposition of random fibers on the uniaxially aligned nanofiber mat in a gradient manner, directed morphological changes of applied adipose-derived stem cells. These morphological changes and resultant biochemical changes can help mimic the structural orientation of complex biomechanical structures like the collagen fiber structure at the tendon-to-bone insertion site. In addition, chemical gradients can be established through nanoencapsulation in this novel scaffold allowing for enhanced biomedical applications.

KW - Electrospinning

KW - Gradient

KW - Nanofibers

KW - Organization

KW - Tendon-to-bone

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Fabrication of Nanofiber Scaffolds With Gradations in Fiber Organization and Their Potential Applications

Abstract

Keywords

ASJC Scopus subject areas

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