Fabrication of Nanofiber Scaffolds With Gradations in Fiber Organization and Their Potential Applications

Jingwei Xie, Bing Ma, Praveesuda Lorwattanapongsa Michael, Franklin D. Shuler

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

A new and simple method for fabrication of nanofiber scaffolds with gradations in fiber organization is reported. The nanofiber organization, achieved by deposition of random fibers on the uniaxially aligned nanofiber mat in a gradient manner, directed morphological changes of applied adipose-derived stem cells. These morphological changes and resultant biochemical changes can help mimic the structural orientation of complex biomechanical structures like the collagen fiber structure at the tendon-to-bone insertion site. In addition, chemical gradients can be established through nanoencapsulation in this novel scaffold allowing for enhanced biomedical applications.

Original languageEnglish (US)
Pages (from-to)1336-1341
Number of pages6
JournalMacromolecular Bioscience
Volume12
Issue number10
DOIs
StatePublished - Oct 1 2012

Keywords

  • Electrospinning
  • Gradient
  • Nanofibers
  • Organization
  • Tendon-to-bone

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

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