TY - GEN
T1 - Facile assembly of large area cell arrays using patterned elastomeric surfaces
AU - Perez-Toralla, Karla
AU - Olivera-Torres, Angel
AU - Rose, Mark
AU - Yang, Ruiguo
AU - Morin, Stephen
N1 - Funding Information:
The authors gratefully acknowledge financial support from the Nebraska Center for Integrated Biomolecular Communication (NCIBC) (NIH National Institutes of General Medical Sciences P20 GM113126).
Publisher Copyright:
© 2019 CBMS-0001.
PY - 2019
Y1 - 2019
N2 - New tools for the rational design of reconfigurable cell arrays that are simple, scalable and easily implemented in tissue engineering and mechanosensing studies are reported here. A surface molding process that relies on the assembly of picoliter droplets into ordered arrays has been developed using micropatterned stretchable substrates. Aerosol microdroplets with cell cargo and uniform size distribution were generated and delivered using a novel microfluidic-based spray nozzle. Efficient cell assembly and proliferation was obtained inside the patterned areas.
AB - New tools for the rational design of reconfigurable cell arrays that are simple, scalable and easily implemented in tissue engineering and mechanosensing studies are reported here. A surface molding process that relies on the assembly of picoliter droplets into ordered arrays has been developed using micropatterned stretchable substrates. Aerosol microdroplets with cell cargo and uniform size distribution were generated and delivered using a novel microfluidic-based spray nozzle. Efficient cell assembly and proliferation was obtained inside the patterned areas.
KW - Aerosol Microfluidics
KW - Cell Arrays
KW - Chemical Patterning
KW - Mechanosensing
UR - http://www.scopus.com/inward/record.url?scp=85094957826&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85094957826&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:85094957826
T3 - 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
SP - 134
EP - 135
BT - 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
PB - Chemical and Biological Microsystems Society
T2 - 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
Y2 - 27 October 2019 through 31 October 2019
ER -