TY - JOUR
T1 - Facilitation by drug states does not depend on acquired excitatory strength
AU - Palmatier, Matthew I.
AU - Bevins, Rick A.
N1 - Funding Information:
This research was partially supported by NIH (DA11893) and the University of Nebraska-Lincoln Research Council. The experiments partially fulfilled the doctoral degree requirements of the first author, who was supported by NIH grant DA16179A. RA Bevins was partially supported by DA018114 while preparing this manuscript. We thank Cody Brooks for his thoughtful comments on a previous version of this manuscript.
PY - 2007/1/25
Y1 - 2007/1/25
N2 - Three experiments examined the effects of drug-extinction when a drug state served as a conditional stimulus (CS) for sucrose delivery or as a positive feature for pairings between a discrete CS (e.g., 15-s light-on) and sucrose. Some conditioning models predict that drug state will facilitate the conditional response (CR) based on an association with sucrose whether the drug is trained as a CS or as a facilitator. If so, repeated presentation of the drug state alone (drug-extinction) should decrease the CR in both situations. Nicotine (0.4 mg/kg), amphetamine (AMP, 1 mg/kg), and chlordiazepoxide (CDP, 5 mg/kg) facilitated a goal tracking conditioned response to the discrete CS; however, AMP and CDP did not evoke reliable responding without an interposed stimulus, suggesting that associations between these drug states and sucrose are not expressed as anticipatory food seeking (goal tracking). Repeated presentation of each drug state alone did not disrupt facilitation by nicotine, amphetamine, or CDP; suggesting that the drug states did not facilitate goal tracking based on a direct association with sucrose. This latter finding implicates a higher-order or non-associative mechanism for facilitation of anticipatory food seeking by drug states in this Pavlovian discrimination task.
AB - Three experiments examined the effects of drug-extinction when a drug state served as a conditional stimulus (CS) for sucrose delivery or as a positive feature for pairings between a discrete CS (e.g., 15-s light-on) and sucrose. Some conditioning models predict that drug state will facilitate the conditional response (CR) based on an association with sucrose whether the drug is trained as a CS or as a facilitator. If so, repeated presentation of the drug state alone (drug-extinction) should decrease the CR in both situations. Nicotine (0.4 mg/kg), amphetamine (AMP, 1 mg/kg), and chlordiazepoxide (CDP, 5 mg/kg) facilitated a goal tracking conditioned response to the discrete CS; however, AMP and CDP did not evoke reliable responding without an interposed stimulus, suggesting that associations between these drug states and sucrose are not expressed as anticipatory food seeking (goal tracking). Repeated presentation of each drug state alone did not disrupt facilitation by nicotine, amphetamine, or CDP; suggesting that the drug states did not facilitate goal tracking based on a direct association with sucrose. This latter finding implicates a higher-order or non-associative mechanism for facilitation of anticipatory food seeking by drug states in this Pavlovian discrimination task.
KW - Addiction
KW - Drug abuse
KW - Learning
KW - Motivation
KW - Occasion setting
KW - Pavlovian conditioning
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U2 - 10.1016/j.bbr.2006.10.015
DO - 10.1016/j.bbr.2006.10.015
M3 - Article
C2 - 17092575
AN - SCOPUS:33845329563
SN - 0166-4328
VL - 176
SP - 292
EP - 301
JO - Behavioural Brain Research
JF - Behavioural Brain Research
IS - 2
ER -