Factors affecting visual outcomes in patients with diabetic macular edema treated with ranibizumab

R. Channa, R. Sophie, A. A. Khwaja, D. V. Do, G. Hafiz, Q. D. Nguyen, P. A. Campochiaro

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

PurposeTo identify factors associated with visual outcomes in patients with diabetic macular edema (DME) treated with ranibizumab (RBZ) in the Ranibizumab for Edema of the mAcula in Diabetes - Protocol 2 (READ-2) Study.Patients and methodsOptical coherence tomography scans, fundus photographs, and fluorescein angiograms (FAs) were graded and along with baseline characteristics were correlated with month (M) 24 visual outcome of best-corrected visual acuity (BCVA) ≤20/100 (poor outcome) vs >20/100 (better outcome).ResultsOf 101 patients with a M20 visit or beyond, 27 (27%) had BCVA ≤20/100. Comparison of patients with or without poor outcome showed mean baseline BCVA of 16.8 letters (20/125) in the former compared with 30.4 letters (20/63; P<0.001). Mean change in BCVA between baseline and M24 was -2.6 letters in the poor outcome group compared with +9.8 letters (P<0.001). Foveal thickness (FTH) at M24 was 374.1 μm in the poor outcome group compared with 268.8 μm (P<0.01), a difference driven by 14 patients with mean FTH of 450.3 μm. Foveal atrophy occurred in 65% (11/17) in the poor outcome group compared with 17%(12/71, P=0.001). Persistent edema was noted in 52% (14/27) of patients with poor outcome. Laser scars near foveal center were significantly more common in patients with poor outcome who did not have edema vs those who did (78% (7/9) vs 23% (3/13) P=0.03).ConclusionPoor baseline BCVA (≤20/125) in DME patients predicts poor visual outcome (≤20/100) after 2 years of treatment with RBZ and/or focal/grid laser, often due to foveal atrophy and/or persistent edema.

Original languageEnglish (US)
Pages (from-to)269-278
Number of pages10
JournalEye (Basingstoke)
Volume28
Issue number3
DOIs
StatePublished - Mar 2014

Keywords

  • Anti-VEGF
  • Diabetic macular edema
  • Macular edema
  • Ranibizumab

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

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    Channa, R., Sophie, R., Khwaja, A. A., Do, D. V., Hafiz, G., Nguyen, Q. D., & Campochiaro, P. A. (2014). Factors affecting visual outcomes in patients with diabetic macular edema treated with ranibizumab. Eye (Basingstoke), 28(3), 269-278. https://doi.org/10.1038/eye.2013.245