TY - JOUR
T1 - Factors associated with prevalent Mycobacterium tuberculosis infection and disease among adolescents and adults exposed to rifampin-resistant tuberculosis in the household
AU - the ACTG A5300/IMPAACT 2003 PHOENIx Feasibility Study Team
AU - Kim, Soyeon
AU - Hesseling, Anneke C.
AU - Wu, Xingye
AU - Hughes, Michael D.
AU - Sarita Shah, N.
AU - Gaikwad, Sanjay
AU - Kumarasamy, Nishi
AU - Mitchell, Erika
AU - Leon, Mey
AU - Gonzales, Pedro
AU - Badal-Faesen, Sharlaa
AU - Lourens, Madeleine
AU - Nerette, Sandy
AU - Shenje, Justin
AU - de Koker, Petra
AU - Nedsuwan, Supalert
AU - Mohapi, Lerato
AU - Chakalisa, Unoda A.
AU - Mngqbisa, Rosie
AU - da Silva Escada, Rodrigo Otávio
AU - Ouma, Samuel
AU - Heckman, Barbara
AU - Naini, Linda
AU - Gupta, Amita
AU - Swindells, Susan
AU - Churchyard, Gavin
AU - Hazra, Rohan
AU - Johnson, Daniel
AU - Rustomjee, Roxana
AU - Siberry, George K.
AU - Smith, Elizabeth
AU - Jones, Lynne
AU - Demers, Anne Marie
AU - Chaisson, Richard E.
AU - Harrington, Mark
AU - Kanade, Savita M.
AU - Nicotera, Janet
AU - Anthony, Patricia
AU - Lane, Christopher
AU - Kadam, Ujwala Amar
AU - Ssenyonga, Ronald
AU - Shahkolahi, Akbar
AU - Man-Zella, Adam
AU - Hovind, Laura
N1 - Publisher Copyright:
© 2023 Kim et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2023/3
Y1 - 2023/3
N2 - Background Understanding factors associated with prevalent Mycobacterium tuberculosis infection and prevalent TB disease in household contacts of patients with drug-resistant tuberculosis (TB) may be useful for TB program staff conducting contact investigations. Methods Using data from a cross-sectional study that enrolled index participants with rifampin-resistant pulmonary TB and their household contacts (HHCs), we evaluated HHCs age ≥15 years for factors associated with two outcomes: Mycobacterium tuberculosis infection and TB disease. Among HHCs who were not already diagnosed with current active TB disease by the TB program, Mycobacterium tuberculosis infection was determined by interferon-gamma release assay (IGRA). TB disease was adjudicated centrally. We fitted logistic regression models using generalized estimating equations. Results Seven hundred twelve HHCs age ≥15 years enrolled from 279 households in eight high-TB burden countries were a median age of 34 years, 63% female, 22% current smokers and 8% previous smokers, 8% HIV-positive, and 11% previously treated for TB. Of 686 with determinate IGRA results, 471 tested IGRA positive (prevalence 68.8% (95% Confidence Interval: 64.6%, 72.8%)). Multivariable modeling showed IGRA positivity was more common in HHCs aged 25-49 years; reporting prior TB treatment; reporting incarceration, substance use, and/or a period of daily alcohol use in the past 12 months; sharing a sleeping room or more evenings spent with the index participant; living with smokers; or living in a home of materials typical of low socioeconomic status. Forty-six (6.5% (95% Confidence Interval: 4.6%, 9.0%)) HHCs age ≥15 years had prevalent TB disease. Multivariable modeling showed higher prevalence of TB disease among HHCs aged ≥50 years; reporting current or previous smoking; reporting a period of daily alcohol use in the past 12 months; and reporting prior TB treatment. Conclusion We identified overlapping and distinct characteristics associated with Mycobacterium tuberculosis infection and TB disease that may be useful for those conducting household TB investigations.
AB - Background Understanding factors associated with prevalent Mycobacterium tuberculosis infection and prevalent TB disease in household contacts of patients with drug-resistant tuberculosis (TB) may be useful for TB program staff conducting contact investigations. Methods Using data from a cross-sectional study that enrolled index participants with rifampin-resistant pulmonary TB and their household contacts (HHCs), we evaluated HHCs age ≥15 years for factors associated with two outcomes: Mycobacterium tuberculosis infection and TB disease. Among HHCs who were not already diagnosed with current active TB disease by the TB program, Mycobacterium tuberculosis infection was determined by interferon-gamma release assay (IGRA). TB disease was adjudicated centrally. We fitted logistic regression models using generalized estimating equations. Results Seven hundred twelve HHCs age ≥15 years enrolled from 279 households in eight high-TB burden countries were a median age of 34 years, 63% female, 22% current smokers and 8% previous smokers, 8% HIV-positive, and 11% previously treated for TB. Of 686 with determinate IGRA results, 471 tested IGRA positive (prevalence 68.8% (95% Confidence Interval: 64.6%, 72.8%)). Multivariable modeling showed IGRA positivity was more common in HHCs aged 25-49 years; reporting prior TB treatment; reporting incarceration, substance use, and/or a period of daily alcohol use in the past 12 months; sharing a sleeping room or more evenings spent with the index participant; living with smokers; or living in a home of materials typical of low socioeconomic status. Forty-six (6.5% (95% Confidence Interval: 4.6%, 9.0%)) HHCs age ≥15 years had prevalent TB disease. Multivariable modeling showed higher prevalence of TB disease among HHCs aged ≥50 years; reporting current or previous smoking; reporting a period of daily alcohol use in the past 12 months; and reporting prior TB treatment. Conclusion We identified overlapping and distinct characteristics associated with Mycobacterium tuberculosis infection and TB disease that may be useful for those conducting household TB investigations.
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U2 - 10.1371/journal.pone.0283290
DO - 10.1371/journal.pone.0283290
M3 - Article
C2 - 36930628
AN - SCOPUS:85150341907
SN - 1932-6203
VL - 18
JO - PloS one
JF - PloS one
IS - 3 March
M1 - e0283290
ER -